Gene Symbol | Papss1 |
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Entrez Gene | 23971 |
Alt Symbol | AI325286, Asapk, SK1 |
Species | Mouse |
Gene Type | protein-coding |
Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
Other Description | PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1 |
Swissprots | Q60967 |
Accessions | EDL12197 EDL12198 Q60967 AK146507 BAE27221 AK153296 BAE31878 AK160875 BAE36063 AK168982 BAE40782 AK169117 BAE40897 AK169124 BAE40904 AK169204 BAE40977 AK209379 AK210041 AK211888 BC066055 AAH66055 CO043332 U34883 AAC52328 NM_001289477 NP_001276406 NM_001289478 NP_001276407 NM_001289479 NP_001276408 NM_011863 NP_035993 |
Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. |
Tissue Specificity | Expressed in the neonatal brain and in cartilage. |
Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |
PAPSS 1 CRISPR/Cas9 KO Plasmid (m) - sc-423927 from Santa Cruz Biotechnology
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PAPSS 1 HDR Plasmid (m) - sc-423927-HDR from Santa Cruz Biotechnology
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PAPSS 1 Double Nickase Plasmid (m) - sc-423927-NIC from Santa Cruz Biotechnology
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PAPSS 1 Double Nickase Plasmid (m2) - sc-423927-NIC-2 from Santa Cruz Biotechnology
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PAPSS 1 CRISPR Activation Plasmid (m) - sc-423927-ACT from Santa Cruz Biotechnology
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PAPSS 1 CRISPR Activation Plasmid (m2) - sc-423927-ACT-2 from Santa Cruz Biotechnology
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PAPSS 1 Lentiviral Activation Particles (m) - sc-423927-LAC from Santa Cruz Biotechnology
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PAPSS 1 Lentiviral Activation Particles (m2) - sc-423927-LAC-2 from Santa Cruz Biotechnology
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PAPSS 1 siRNA (m) - sc-61292 from Santa Cruz Biotechnology
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PAPSS 1 shRNA Plasmid (m) - sc-61292-SH from Santa Cruz Biotechnology
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PAPSS 1 shRNA (m) Lentiviral Particles - sc-61292-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN38243 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38243 from Sigma-Aldrich
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PAPSS1 siRNA (Mouse) - CRM4611 from Cohesion Biosciences
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shRNA set against Mouse PAPSS1 (NM_011863.2) - SHH370552 from Creative biogene
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Mouse PAPSS1 siRNA - orb284087 from Biorbyt
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PAPSS1 shRNA Plasmid (Mouse) - CHM4611 from Cohesion Biosciences
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