| Gene Symbol | SFTPA1 |
|---|---|
| Entrez Gene | 653509 |
| Alt Symbol | COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | surfactant protein A1 |
| Other Description | 35 kDa pulmonary surfactant-associated protein|alveolar proteinosis protein|collectin-4|pulmonary surfactant-associated protein A1|surfactant protein A1 variant AB'D' 6A|surfactant protein A1 variant AB'D' 6A2|surfactant protein A1 variant AB'D' 6A3|surfactant protein A1 variant AB'D' 6A4|surfactant protein A1 variant ACD' 6A|surfactant protein A1 variant ACD' 6A2|surfactant protein A1 variant ACD' 6A3|surfactant protein A1 variant ACD' 6A4|surfactant protein A1 variant AD' 6A|surfactant protein A1 variant AD' 6A2|surfactant protein A1 variant AD' 6A3|surfactant protein A1 variant AD' 6A4|surfactant protein A1B|surfactant, pulmonary-associated protein A1A|surfactant, pulmonary-associated protein A1B |
| Swissprots | E3VLE0 Q6PIT0 Q5RIR5 Q8TC19 G5E9J3 E3VLD8 B7ZW50 E3VLE1 A8K3T8 E3VLD9 Q14DV4 Q5RIR7 Q8IWL2 |
| Accessions | AAO13486 EAW54657 EAW54658 EAW54659 EAW54660 Q8IWL2 AK290703 BAF83392 AK298002 BAG60308 AK298029 BAG60331 AK298034 BAG60335 AK298092 BAG60377 AK309518 AK316196 BAH14567 BC026229 BC029913 AAH29913 BC111570 AAI11571 BC171875 AAI71875 BI820937 BM996243 DA588383 HQ021433 ADO27676 HQ021434 ADO27677 HQ021435 ADO27678 HQ021436 ADO27679 HQ021437 ADO27680 HQ021438 ADO27681 HQ021439 ADO27682 HQ021440 ADO27683 HQ021441 ADO27684 HQ021442 ADO27685 JX502764 AFV36787 JX502765 AFV36788 XM_005270062 XP_005270119 XM_006717953 XP_006718016 NM_001093770 NP_001087239 NM_001164644 NP_001158116 NM_001164645 NP_001158117 NM_001164646 NP_001158118 NM_001164647 NP_001158119 NM_005411 NP_005402 |
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
| Top Pathways | Phagosome, Pertussis |
SP-A1 CRISPR/Cas9 KO Plasmid (h) - sc-400974 from Santa Cruz Biotechnology
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SP-A1 HDR Plasmid (h) - sc-400974-HDR from Santa Cruz Biotechnology
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SP-A1 Double Nickase Plasmid (h) - sc-400974-NIC from Santa Cruz Biotechnology
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SP-A1 Double Nickase Plasmid (h2) - sc-400974-NIC-2 from Santa Cruz Biotechnology
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SP-A1 CRISPR Activation Plasmid (h) - sc-400974-ACT from Santa Cruz Biotechnology
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SP-A1 CRISPR Activation Plasmid (h2) - sc-400974-ACT-2 from Santa Cruz Biotechnology
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SP-A1 Lentiviral Activation Particles (h) - sc-400974-LAC from Santa Cruz Biotechnology
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SP-A1 Lentiviral Activation Particles (h2) - sc-400974-LAC-2 from Santa Cruz Biotechnology
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SP-A siRNA (h) - sc-36535 from Santa Cruz Biotechnology
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SP-A shRNA Plasmid (h) - sc-36535-SH from Santa Cruz Biotechnology
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SP-A shRNA (h) Lentiviral Particles - sc-36535-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN19208 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19208 from Sigma-Aldrich
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SFTPA1 siRNA (Human) - CRJ8582 from Cohesion Biosciences
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SFTPA1 - MBS8213959 from MyBioSource
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SFTPA1 shRNA Plasmid (Human) - CHJ8582 from Cohesion Biosciences
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SFTPA1 miRNA 3'UTR clone - MiUTR1H-04399 from Creative biogene
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SFTPA1 miRNA 3'UTR clone - MiUTR1H-04400 from Creative biogene
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SFTPA1 miRNA 3'UTR clone - MiUTR1H-04401 from Creative biogene
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SFTPA1 miRNA 3'UTR clone - MiUTR1H-04402 from Creative biogene
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SFTPA1 miRNA 3'UTR clone - MiUTR1H-04403 from Creative biogene
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SFTPA1 miRNA 3'UTR clone - MiUTR4H-TG07998 from Creative biogene
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