| Gene Symbol |
RAB14
|
| Entrez Gene |
51552
|
| Alt Symbol |
FBP, RAB-14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB14, member RAS oncogene family
|
| Other Description |
F protein-binding protein 1|bA165P4.3 (member RAS oncogene family)|ras-related protein Rab-14|small GTP binding protein RAB14
|
| Swissprots |
Q9UI11 Q5JVD4 Q969L0 Q6Q7K5 B3KR31 P61106 P35287
|
| Accessions |
EAW87487 EAW87488 P61106 AF052113 AF112206 AAF17194 AF152463 AAF00150 AF203689 AAF19400 AF498949 AAM21097 AK000447 AK023524 BAB14598 AK090889 BAG52243 AL110256 AL162081 CAB82414 AM393292 CAL38170 AM393350 CAL38228 AY553875 AAS64573 BC006081 AAH06081 BC013057 CR457394 CAG33675 DA404780 NM_016322 NP_057406
|
| Function |
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion. {ECO:0000250, ECO:0000269|PubMed:22595670}.
|
| Subcellular Location |
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Top Pathways |
AMPK signaling pathway
|
![Western Blot: RAB14 Overexpression Lysate (Adult Normal) [NBL1-15041] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10265_RAB14%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15041-img0002.jpg)