Gene Symbol | ACSM2B |
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Entrez Gene | 348158 |
Alt Symbol | ACSM2, HXMA, HYST1046 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA synthetase medium-chain family member 2B |
Other Description | acyl-CoA synthetase medium-chain family member 2|acyl-coenzyme A synthetase ACSM2B, mitochondrial|butyrate--CoA ligase 2B|butyryl-coenzyme A synthetase 2B|middle-chain acyl-CoA synthetase 2B|xenobiotic/medium-chain fatty acid-CoA ligase HXM-A|xenobiotic/medium-chain fatty acid:CoA ligase |
Swissprots | Q86YT1 Q68CK6 |
Accessions | Q68CK6 AB073604 BAD38642 AK129944 AK289416 BAF82105 AK309601 AY160217 AAO17576 BC026010 BC172335 AAI72335 DC329427 DC362610 DC362960 DC362964 DC412825 XM_005255304 XP_005255361 XM_011545824 XP_011544126 NM_001105069 NP_001098539 NM_182617 NP_872423 |
Function | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000269|PubMed:12616642}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10434065, ECO:0000269|PubMed:12616642, ECO:0000269|PubMed:19634011}. |
Tissue Specificity | Detected in liver. {ECO:0000269|PubMed:10434065, ECO:0000269|PubMed:19634011}. |
Top Pathways | Butanoate metabolism |
ACSM2B CRISPR/Cas9 KO Plasmid (h) - sc-415643 from Santa Cruz Biotechnology
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ACSM2B HDR Plasmid (h) - sc-415643-HDR from Santa Cruz Biotechnology
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ACSM2B Double Nickase Plasmid (h) - sc-415643-NIC from Santa Cruz Biotechnology
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ACSM2B Double Nickase Plasmid (h2) - sc-415643-NIC-2 from Santa Cruz Biotechnology
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ACSM2B CRISPR Activation Plasmid (h) - sc-415643-ACT from Santa Cruz Biotechnology
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ACSM2B CRISPR Activation Plasmid (h2) - sc-415643-ACT-2 from Santa Cruz Biotechnology
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ACSM2B Lentiviral Activation Particles (h) - sc-415643-LAC from Santa Cruz Biotechnology
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ACSM2B Lentiviral Activation Particles (h2) - sc-415643-LAC-2 from Santa Cruz Biotechnology
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ACSM2B siRNA (h) - sc-93493 from Santa Cruz Biotechnology
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ACSM2B shRNA Plasmid (h) - sc-93493-SH from Santa Cruz Biotechnology
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ACSM2B shRNA (h) Lentiviral Particles - sc-93493-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU106631 from Sigma-Aldrich
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MISSION® esiRNA - EHU111491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2759 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2759 from Sigma-Aldrich
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ACSM2B siRNA (Human) - CRJ7528 from Cohesion Biosciences
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ACSM2B - MBS8216329 from MyBioSource
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shRNA set against Human ACSM2B (NM_182617.3) - SHH230806 from Creative biogene
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shRNA set against Human ACSM2(NM_182617.3) - SHG035747 from Creative biogene
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Human ACSM2B siRNA - orb278029 from Biorbyt
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ACSM2B shRNA Plasmid (Human) - CHJ7528 from Cohesion Biosciences
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ACSM2B miRNA 3'UTR clone - MiUTR1H-00128 from Creative biogene
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ACSM2B miRNA 3'UTR clone - MiUTR3H-13221 from Creative biogene
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