Gene Symbol | GNPTG |
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Entrez Gene | 84572 |
Alt Symbol | C16orf27, GNPTAG, LP2537, RJD9 |
Species | Human |
Gene Type | protein-coding |
Description | N-acetylglucosamine-1-phosphate transferase, gamma subunit |
Other Description | N-acetylglucosamine-1-phosphotransferase subunit gamma|UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma|glcNAc-1-phosphotransferase subunit gamma |
Swissprots | Q96L13 B2R556 Q9UJJ9 Q6XYD7 |
Accessions | AAK61277 EAW85666 EAW85667 EAW85668 Q9UJJ9 AA513392 AF302786 AAG27706 AK126110 AK312067 BAG35003 AY203933 AAP34456 BC014592 AAH14592 BC131525 AAI31526 BU145878 BX398427 CD671181 DQ890827 ABM81753 DQ893981 ABM84907 DT219524 NM_032520 NP_115909 |
Function | Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. {ECO:0000269|PubMed:10712439, ECO:0000269|PubMed:19955174}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:15532026}. Golgi apparatus {ECO:0000269|PubMed:15532026}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10712439}. |
Top Pathways | Lysosome |
GNPTG CRISPR/Cas9 KO Plasmid (h) - sc-413670 from Santa Cruz Biotechnology
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GNPTG HDR Plasmid (h) - sc-413670-HDR from Santa Cruz Biotechnology
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GNPTG Double Nickase Plasmid (h) - sc-413670-NIC from Santa Cruz Biotechnology
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GNPTG Double Nickase Plasmid (h2) - sc-413670-NIC-2 from Santa Cruz Biotechnology
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GNPTG CRISPR Activation Plasmid (h) - sc-413670-ACT from Santa Cruz Biotechnology
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GNPTG CRISPR Activation Plasmid (h2) - sc-413670-ACT-2 from Santa Cruz Biotechnology
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GNPTG Lentiviral Activation Particles (h) - sc-413670-LAC from Santa Cruz Biotechnology
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GNPTG Lentiviral Activation Particles (h2) - sc-413670-LAC-2 from Santa Cruz Biotechnology
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GNPTG siRNA (h) - sc-93496 from Santa Cruz Biotechnology
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GNPTG shRNA Plasmid (h) - sc-93496-SH from Santa Cruz Biotechnology
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GNPTG shRNA (h) Lentiviral Particles - sc-93496-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9447 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9447 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01837 from Sigma-Aldrich
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GNPTG siRNA (Human) - CRJ3529 from Cohesion Biosciences
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GNPTG - MBS8226597 from MyBioSource
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shRNA set against Human GNPTG (NM_032520.4) - SHH305102 from Creative biogene
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Human GNPTG siRNA - orb274030 from Biorbyt
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GNPTG shRNA Plasmid (Human) - CHJ3529 from Cohesion Biosciences
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GNPTG miRNA 3'UTR clone - MiUTR3H-09500 from Creative biogene
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