| Gene Symbol | TAP2 |
|---|---|
| Entrez Gene | 6891 |
| Alt Symbol | ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| Other Description | ABC transporter, MHC 2|ATP-binding cassette, sub-family B (MDR/TAP), member 3|antigen peptide transporter 2|peptide supply factor 2|peptide transporter PSF2|peptide transporter involved in antigen processing 2|really interesting new gene 11 protein|transporter 2, ABC (ATP binding cassette) |
| Swissprots | Q9UQ83 Q96PT8 Q5HY71 O95410 B0V2J8 Q03519 Q53FI6 |
| Accessions | AAG12163 AAL07496 AHW47924 AHW47941 AHW47958 AHW47975 BAA07665 BAA11414 CAA47027 CAA60788 EAX03642 EAX03643 Q03519 AB073779 BAB71769 AB208953 BAD92190 AF078671 AAD31384 AF105151 AAD12059 AF152583 AAD32715 AF176984 AAD50509 AK222823 BAD96543 AK223300 BAD97020 AK225657 AK225693 AK292963 BAF85652 AL833658 BC002751 BC152839 AAI52840 BG423357 BT009906 AAP88908 DC345324 EU832685 ACE87017 FM246456 CAR92541 L09191 AAA58648 L09271 L10287 AAA58649 M74447 AAA59841 M84748 U07844 AAA79901 Z22935 CAA80522 Z22936 CAA80523 NM_000544 NP_000535 NM_001290043 NP_001276972 NM_018833 NP_061313 |
| Function | Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane. |
| Top Pathways | ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation |