TAP2

Gene Symbol	TAP2
Entrez Gene	6891
Alt Symbol	ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11
Species	Human
Gene Type	protein-coding
Description	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Other Description	ABC transporter, MHC 2|ATP-binding cassette, sub-family B (MDR/TAP), member 3|antigen peptide transporter 2|peptide supply factor 2|peptide transporter PSF2|peptide transporter involved in antigen processing 2|really interesting new gene 11 protein|transporter 2, ABC (ATP binding cassette)
Swissprots	Q9UQ83 Q96PT8 Q5HY71 O95410 B0V2J8 Q03519 Q53FI6
Accessions	AAG12163 AAL07496 AHW47924 AHW47941 AHW47958 AHW47975 BAA07665 BAA11414 CAA47027 CAA60788 EAX03642 EAX03643 Q03519 AB073779 BAB71769 AB208953 BAD92190 AF078671 AAD31384 AF105151 AAD12059 AF152583 AAD32715 AF176984 AAD50509 AK222823 BAD96543 AK223300 BAD97020 AK225657 AK225693 AK292963 BAF85652 AL833658 BC002751 BC152839 AAI52840 BG423357 BT009906 AAP88908 DC345324 EU832685 ACE87017 FM246456 CAR92541 L09191 AAA58648 L09271 L10287 AAA58649 M74447 AAA59841 M84748 U07844 AAA79901 Z22935 CAA80522 Z22936 CAA80523 NM_000544 NP_000535 NM_001290043 NP_001276972 NM_018833 NP_061313
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Top Pathways	ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TAP2 full length protein - ab132658 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human TAP2 Protein - H00006891-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

TAP2 Recombinant Protein - H00006891-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LYPLA2 protein (His tag) - 80R-1684 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

ABCB3 / APT2 / TAP2 - H00006891-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ABCB3 / APT2 / TAP2 - H00006891-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ABCB3 / APT2 / TAP2 - H00006891-P02-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ABCB3 / APT2 / TAP2 - H00006891-P02-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

TAP2 (MDR/TAP) - H00006891-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

TAP2 fusion protein - ag0190 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Antigen Peptide Transporter 2 (TAP2) - RPD112Hu01 from Uscn Life Science Inc. Category Peptide Source E.coli Species Human

Recombinant Antigen Peptide Transporter 2 (TAP2) - RPD112Ra01 from Uscn Life Science Inc. Category Peptide Source E.coli Species Rat

TAP2 Recombinant Protein Antigen - NBP1-89312PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TAP2-Antibody-C-term-Blocking-Peptide - BP6253a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAP2 Peptide, Human - M34GP15577H from Creative Peptides Category Peptide Source Synthetic. Species Human

TAP2 Recombinant Protein (OPCD00376) - OPCD00376 from Aviva Systems Biology Category Protein Source E.coli Species Human

Protein TAP2 (TAP2), Recombinant Protein - MBS1067641 from MyBioSource Category Protein Prices $845.00, $845.00, $1,065.00, $1,065.00, $1,215.00, $1,215.00, $1,670.00, $1,670.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human TAP2 Protein, GST-tagged - TAP2-660H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human TAP2 protein, His & T7-tagged - TAP2-7880H from Creative Biomart Category Protein Source E. coli Species Human

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