| Gene Symbol |
TBCB
|
| Entrez Gene |
1155
|
| Alt Symbol |
CG22, CKAP1, CKAPI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin folding cofactor B
|
| Other Description |
cytoskeleton associated protein 1|cytoskeleton-associated protein CKAPI|tubulin-folding cofactor B|tubulin-specific chaperone B
|
| Swissprots |
O00674 Q99426 Q6FGY5 O14728 O00111
|
| Accessions |
AAB51182 CAH05698 CAR82347 Q99426 AF013488 AAB67716 AI126083 AI148860 AL555345 BC005969 AAH05969 BC052812 AAH52812 BQ923739 BT007424 AAP36092 CR541971 CAG46769 CR996176 D49738 BAA08572 DQ892900 ABM83826 DQ896150 ABM87149 NM_001281 NP_001272 NM_001300971 NP_001287900
|
| Function |
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15831477}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
|
| Tissue Specificity |
Found in most tissues.
|