WNK1

Gene Symbol	WNK1
Entrez Gene	65125
Alt Symbol	HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65
Species	Human
Gene Type	protein-coding
Description	WNK lysine deficient protein kinase 1
Other Description	WNK lysine deficient protein kinase 1 isoform|erythrocyte 65 kDa protein|prostate-derived sterile 20-like kinase|protein kinase with no lysine 1|protein phosphatase 1, regulatory subunit 167|serine/threonine-protein kinase WNK1
Swissprots	Q8N673 Q6IFS5 O15052 Q9H4A3 Q9P1S9 P54963 C5HTZ6 Q4VBX9 C5HTZ5 Q86WL5 C5HTZ7 Q96CZ6 A1L4B0 H6WZW3
Accessions	ACS13726 DAA04494 EAW88951 EAW88952 EAW88953 EAW88954 EAW88955 EAW88956 EAW88957 EAW88958 Q9H4A3 AB002342 BAA20802 AF061944 AAF31483 AI074334 AJ296290 CAC15059 AY231477 AAO46160 BC013629 AAH13629 BC021121 BC035146 BC044600 BC071959 BC094862 BC130467 AAI30468 BC130469 AAI30470 BC141881 AAI41882 BC172444 AAI72444 BJ997509 BM716053 BX644268 CD629562 DA720959 DQ925669 ABL59896 DQ925671 ABL59898 DQ925672 ABL59899 JQ358908 AEY99342 N57692 XM_006719003 XP_006719066 XM_011520997 XP_011519299 XM_011520998 XP_011519300 XM_011520999 XP_011519301 XM_011521000 XP_011519302 XM_011521001 XP_011519303 XM_011521002 XP_011519304 XM_011521003 XP_011519305 XM_011521004 XP_011519306 XM_011521005 XP_011519307 XM_011521006 XP_011519308 XM_011521007 XP_011519309 XM_011521008 XP_011519310 XM_011521009 XP_011519311 NM_001184985 NP_001171914 NM_014823 NP_055638 NM_018979 NP_061852 NM_213655 NP_998820
Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15060842}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10660600}.
Tissue Specificity	Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:14645531, ECO:0000269|PubMed:22701532}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-WNK1 (Thr60) Antibody - 4946 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

WNK1 Antibody - 4979 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

WNK1 (S-15) - sc-168111 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WNK1 (Q-15) - sc-168110 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WNK1 (N-20) - sc-20468 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WNK1 (H-130) - sc-28897 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

WNK1 (C-19) - sc-20470 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-WNK1 (phospho T58) antibody - ab53137 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 antibody - ab53151 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 antibody - ab137687 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 antibody - ab35069 from Abcam Prices $376.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 antibody - ab113492 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 antibody [EPR2726(3)] - ab128858 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2726(3)

Anti-WNK1 antibody [EPR2743(3)] - ab174854 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2743(3)

Anti-WNK1 antibody [EPR2744(3)] - ab181029 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2744(3)

Anti-WNK1 Antibody (C-Terminus) IHC-plus™ - LS-A7959 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (Internal) IHC-plus™ - LS-A7494 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (C-Terminus) - LS-C2940 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (N-Terminus) - LS-C11063 from LifeSpan Bioscience Prices $415.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (N-Terminus) - LS-C11065 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (C-Terminus) - LS-C90504 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (C-Terminus, Biotin) - LS-C142323 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (C-Terminus, DY650) - LS-C142324 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (Internal) IHC-plus™ - LS-A7484 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-WNK1 Antibody (C-Terminus, HRP) - LS-C142326 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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