| Gene Symbol |
ARIH2
|
| Entrez Gene |
10425
|
| Alt Symbol |
ARI2, TRIAD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ariadne RBR E3 ubiquitin protein ligase 2
|
| Other Description |
ARI-2|E3 ubiquitin-protein ligase ARIH2|all-trans retinoic acid inducible RING finger|ariadne homolog 2|protein ariadne-2 homolog
|
| Swissprots |
O95376 Q9UEM9 Q9HBZ6
|
| Accessions |
EAW64930 EAW64931 EAW64932 EAW64933 O95376 AB208857 BAD92094 AF099149 AAC82469 AF099150 AF099151 AF099152 AF099153 AF113677 AF183427 AAG09696 AJ130978 CAA10276 AK001800 BAG50977 AK091240 AK223550 BAD97270 AK307694 AK313434 BAG36225 AL110187 AL162034 BC000422 AAH00422 CN399800 CR456785 CAG33066 DQ895018 ABM85944 XM_005264798 XP_005264855 XM_011533265 XP_011531567 XM_011533266 XP_011531568 XM_011533267 XP_011531569 XM_011533268 XP_011531570 XM_011533269 XP_011531571 XM_011533270 XP_011531572 XM_011533271 XP_011531573 XM_011533272 XP_011531574 XM_011533273 XP_011531575 XM_011533274 XP_011531576 XM_011533275 XP_011531577 XM_011533276 XP_011531578 XR_940362 NM_006321 NP_006312
|
| Function |
E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006}.
|
| Subcellular Location |
Nucleus. Cytoplasm.
|
| Tissue Specificity |
Widely expressed with higher expression in granulocytes. {ECO:0000269|PubMed:16118314}.
|