| Gene Symbol |
ICE2
|
| Entrez Gene |
79664
|
| Alt Symbol |
BRCC1, NARG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interactor of little elongation complex ELL subunit 2
|
| Other Description |
NMDA receptor regulated 2|NMDA receptor-regulated gene 2|NMDA receptor-regulated protein 2|breast cancer cell 1|interactor of little elongator complex ELL subunit 2|little elongation complex subunit 2
|
| Swissprots |
Q63HP4 Q96CY5 Q68CN8 Q71H65 B2RU08 Q9HAA2 Q658Q0 Q6UX23 Q659A1 Q05CT1 Q6IPW7 Q3B7W6
|
| Accessions |
EAW77588 EAW77589 EAW77590 Q659A1 AF502591 AAQ07460 AK021958 BAB13948 AK055752 BAG51567 AK095389 AK127892 BAG54594 AL832046 CAH56220 AL833122 CAH56202 AL833318 AY358546 AAQ88910 BC013684 AAH13684 BC020918 AAH20918 BC071685 AAH71685 BC107427 AAI07428 BC140894 AAI40895 BC151844 BU738348 BX647873 CAH56197 CN342776 CR749852 CAH18700 XM_005254661 XP_005254718 XM_005254662 XP_005254719 XM_011522009 XP_011520311 XM_011522010 XP_011520312 XM_011522011 XP_011520313 XR_931902 XR_931903 XR_931904 NM_001018089 NP_001018099 NM_001276385 NP_001263314 NM_024611 NP_078887
|
| Function |
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
|
| Tissue Specificity |
Expressed at low levels in lung and testis. {ECO:0000269|PubMed:15606750}.
|