| Gene Symbol |
SLC7A8
|
| Entrez Gene |
23428
|
| Alt Symbol |
LAT2, LPI-PC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 7 (amino acid transporter light chain, L system), member 8
|
| Other Description |
L-type amino acid transporter 2|integral membrane protein E16H|large neutral amino acids transporter small subunit 2|solute carrier family 7 (amino acid transporter, L-type), member 8|solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
|
| Swissprots |
D3DS46 Q9UKQ6 Q9Y445 Q9UKQ8 B2R8Q4 Q9UHI5 Q86U05 B4DKT4 Q9UKQ7 F2Z2J4 B4DTV6
|
| Accessions |
EAW66181 EAW66182 Q9UHI5 AB037669 BAB21519 AF087908 AAP97206 AF087911 AAP97208 AF135828 AAF05695 AF135829 AAF05696 AF135830 AAF05697 AF171669 AAF20381 AK094550 BAG52886 AK223610 BAD97330 AK296702 BAG59296 AK300384 BAG62118 AK307609 AK313465 BAG36251 AL365342 AL365343 AL365344 AL365345 AL365346 AL365347 AL365414 BC036825 AAH36825 BC052250 AAH52250 BX248288 CAD62616 DC348596 Y18483 CAB40137 NM_001267036 NP_001253965 NM_001267037 NP_001253966 NM_012244 NP_036376 NM_182728 NP_877392 NR_049767
|
| Function |
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:1057497
|
| Subcellular Location |
Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.
|
| Tissue Specificity |
Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2. {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:16027961}.
|
| Top Pathways |
Protein digestion and absorption
|
