| Gene Symbol |
Pla2g16
|
| Entrez Gene |
24913
|
| Alt Symbol |
HRSL3, Hrasls3, Hrev107
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group XVI
|
| Other Description |
H-rev 107 protein|HRAS like suppressor 3|HRAS-like suppressor 3|Hras-revertant gene 107 (expression down-regulated in HRAS-transformed rat 208F fibroblasts)|group XVI phospholipase A1/A2|group XVI phospholipase A2
|
| Swissprots |
B7X6T2 P53817
|
| Accessions |
EDM12684 EDM12685 P53817 AB298805 BAH08634 CB613004 CB794299 FQ224126 XM_006230687 XP_006230749 NM_017060 NP_058756
|
| Function |
Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:8290259}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8290259}. Membrane {ECO:0000269|PubMed:8290259}; Single-pass membrane protein {ECO:0000269|PubMed:8290259}.
|
| Tissue Specificity |
Specifically expressed in H-ras resistant fibroblasts. {ECO:0000269|PubMed:18614531, ECO:0000269|PubMed:8290259}.
|
| Top Pathways |
Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Glycerophospholipid metabolism
|