| Gene Symbol | FHOD3 |
|---|---|
| Entrez Gene | 80206 |
| Alt Symbol | FHOS2, Formactin2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | formin homology 2 domain containing 3 |
| Other Description | FH1/FH2 domain-containing protein 3|formactin-2|formin homolog overexpressed in spleen 2|hFHOS2 |
| Swissprots | Q86TF9 Q9H6G7 Q9C0G8 A8MQT4 Q6ZRQ7 Q2V2M9 Q8N3A5 Q9H604 Q642I2 E5F5Q0 |
| Accessions | EAX01379 EAX01380 EAX01381 EAX01382 Q2V2M9 AB051482 BAB21786 AB084087 BAC67014 AK025950 BAB15292 AK026370 BAB15463 AK091899 BAG52438 AK128053 BAC87252 AK308859 AL834480 CAD39139 BC031518 BC041040 BC050670 AAH50670 BC058897 BC081563 AAH81563 BC156314 AAI56315 BC157093 AAI57094 HM191478 ADL62709 HY020952 XM_005258349 XP_005258406 XM_005258352 XP_005258409 XM_005258354 XP_005258411 XM_005258355 XP_005258412 XM_011526189 XP_011524491 XM_011526190 XP_011524492 XM_011526191 XP_011524493 XM_011526192 XP_011524494 XM_011526193 XP_011524495 XM_011526194 XP_011524496 XM_011526195 XP_011524497 XM_011526196 XP_011524498 XM_011526197 XP_011524499 NM_001281739 NP_001268668 NM_001281740 NP_001268669 NM_025135 NP_079411 |
| Function | Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21149568}. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}. |
| Tissue Specificity | Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level). {ECO:0000269|PubMed:15966898, ECO:0000269|PubMed:21149568}. |
FHOD3 CRISPR/Cas9 KO Plasmid (h) - sc-405102 from Santa Cruz Biotechnology
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FHOD3 HDR Plasmid (h) - sc-405102-HDR from Santa Cruz Biotechnology
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FHOD3 Double Nickase Plasmid (h) - sc-405102-NIC from Santa Cruz Biotechnology
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FHOD3 Double Nickase Plasmid (h2) - sc-405102-NIC-2 from Santa Cruz Biotechnology
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FHOD3 CRISPR Activation Plasmid (h) - sc-405102-ACT from Santa Cruz Biotechnology
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FHOD3 CRISPR Activation Plasmid (h2) - sc-405102-ACT-2 from Santa Cruz Biotechnology
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FHOD3 Lentiviral Activation Particles (h) - sc-405102-LAC from Santa Cruz Biotechnology
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FHOD3 Lentiviral Activation Particles (h2) - sc-405102-LAC-2 from Santa Cruz Biotechnology
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FHOD3 siRNA (h) - sc-75015 from Santa Cruz Biotechnology
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FHOD3 shRNA Plasmid (h) - sc-75015-SH from Santa Cruz Biotechnology
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FHOD3 shRNA (h) Lentiviral Particles - sc-75015-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8687 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8687 from Sigma-Aldrich
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FHOD3 siRNA (Human) - CRJ2800 from Cohesion Biosciences
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FHOD3 - MBS8212907 from MyBioSource
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shRNA set against Human FHOD3 (NM_025135.2) - SHH294921 from Creative biogene
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shRNA set against Human FHOD3(NM_025135.2) - SHH059689 from Creative biogene
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Human FHOD3 siRNA - orb273301 from Biorbyt
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FHOD3 shRNA Plasmid (Human) - CHJ2800 from Cohesion Biosciences
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FHOD3 miRNA 3'UTR clone - MiUTR1H-03654 from Creative biogene
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