Gene Symbol | CST4 |
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Entrez Gene | 1472 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cystatin S |
Other Description | cystatin 4|cystatin-4|cystatin-S|cystatin-SA-III|salivary acidic protein 1 |
Swissprots | Q9UCS9 Q9UBI5 P01036 |
Accessions | AAB24493 AAK11571 EAX10135 P01036 BC065714 AAH65714 BC074952 AAH74952 BC074953 AAH74953 HQ447582 ADQ32068 X54667 CAA38478 NM_001899 NP_001890 |
Function | This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. |
Subcellular Location | Secreted {ECO:0000269|PubMed:20189825}. |
Tissue Specificity | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}. |
Top Pathways | Salivary secretion |
cystatin S CRISPR/Cas9 KO Plasmid (h) - sc-416501 from Santa Cruz Biotechnology
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cystatin S HDR Plasmid (h) - sc-416501-HDR from Santa Cruz Biotechnology
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cystatin S Double Nickase Plasmid (h) - sc-416501-NIC from Santa Cruz Biotechnology
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cystatin S Double Nickase Plasmid (h2) - sc-416501-NIC-2 from Santa Cruz Biotechnology
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cystatin S CRISPR Activation Plasmid (h) - sc-416501-ACT from Santa Cruz Biotechnology
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cystatin S CRISPR Activation Plasmid (h2) - sc-416501-ACT-2 from Santa Cruz Biotechnology
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cystatin S Lentiviral Activation Particles (h) - sc-416501-LAC from Santa Cruz Biotechnology
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cystatin S Lentiviral Activation Particles (h2) - sc-416501-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6673 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6673 from Sigma-Aldrich
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CST4 siRNA (Human) - CRH1040 from Cohesion Biosciences
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CST4 - MBS8228923 from MyBioSource
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shRNA set against Human CST4 (NM_001899.2) - SHH270753 from Creative biogene
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Human CST4 siRNA - orb261542 from Biorbyt
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CST4 shRNA Plasmid (Human) - CHH1040 from Cohesion Biosciences
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CST4 miRNA 3'UTR clone - MiUTR1H-02494 from Creative biogene
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