| Gene Symbol | GALNT13 |
|---|---|
| Entrez Gene | 114805 |
| Alt Symbol | GalNAc-T13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypeptide N-acetylgalactosaminyltransferase 13 |
| Other Description | GalNAc transferase 13|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)|polypeptide GalNAc transferase 13|pp-GaNTase 13|protein-UDP acetylgalactosaminyltransferase 13 |
| Swissprots | Q6ZWG1 Q68VI8 Q9UIE5 Q8IUC8 Q08ER7 Q96PX0 |
| Accessions | AAF19246 CAG32964 CCQ43807 EAX11464 EAX11465 Q8IUC8 AB067505 BAB67811 AB078142 BAC54545 AJ505991 CAD44533 AK123152 BAC85542 AK131195 BAG54747 AK308615 AK308675 BC101031 AAI01032 BC101032 AAI01033 BC101033 AAI01034 BC101034 AAI01035 BG221433 CN267103 HY107944 KJ534843 AHW56483 KJ535058 AHW56697 R38990 XM_011510537 XP_011508839 XM_011510538 XP_011508840 NM_001301627 NP_001288556 NM_052917 NP_443149 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Specifically expressed in neuronal cells. Expressed in fetal brain, whole adult brain, cerebral cortex and cerebellum. Not expressed in other tissues tested. {ECO:0000269|PubMed:12407114}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T13 CRISPR/Cas9 KO Plasmid (h) - sc-407103 from Santa Cruz Biotechnology
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GalNAc-T13 HDR Plasmid (h) - sc-407103-HDR from Santa Cruz Biotechnology
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GalNAc-T13 Double Nickase Plasmid (h) - sc-407103-NIC from Santa Cruz Biotechnology
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GalNAc-T13 Double Nickase Plasmid (h2) - sc-407103-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T13 CRISPR Activation Plasmid (h) - sc-407103-ACT from Santa Cruz Biotechnology
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GalNAc-T13 CRISPR Activation Plasmid (h2) - sc-407103-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T13 Lentiviral Activation Particles (h) - sc-407103-LAC from Santa Cruz Biotechnology
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GalNAc-T13 Lentiviral Activation Particles (h2) - sc-407103-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T13 siRNA (h) - sc-75090 from Santa Cruz Biotechnology
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GalNAc-T13 shRNA Plasmid (h) - sc-75090-SH from Santa Cruz Biotechnology
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GalNAc-T13 shRNA (h) Lentiviral Particles - sc-75090-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9105 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9105 from Sigma-Aldrich
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GALNT13 siRNA (Human) - CRJ4388 from Cohesion Biosciences
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GALNT13 - MBS8241332 from MyBioSource
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GalNAc-T13 CRISPR/Cas9 KO Plasmid (h2) - sc-407103-KO-2 from Santa Cruz Biotechnology
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GalNAc-T13 HDR Plasmid (h2) - sc-407103-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GALNT13 (NM_052917.2) - SHH299005 from Creative biogene
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shRNA set against Human GALNT13(NM_052917.2) - SHH076065 from Creative biogene
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GALNT13 shRNA Plasmid (Human) - CHJ4388 from Cohesion Biosciences
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GALNT13 miRNA 3'UTR clone - MiUTR1H-03937 from Creative biogene
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