BNP
| Gene Symbol | BNP |
|---|---|
| Entrez Gene | 396844 |
| Alt Symbol | BNP1, NPPB |
| Species | Pig |
| Gene Type | protein-coding |
| Description | brain natriuretic peptide |
| Other Description | gamma-brain natriuretic peptide|natriuretic peptides B |
| Swissprots | P07634 |
| Accessions | AAA31007 P07634 M23596 AAB59258 NM_213846 NP_999011 |
| Function | Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Brain and also in atria, but at much lower levels than ANP. |
| Top Pathways | cGMP-PKG signaling pathway |
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