| Gene Symbol | ST3GAL4 |
|---|---|
| Entrez Gene | 6484 |
| Alt Symbol | CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4|SAT-3|SIAT4-C|ST-4|ST3GalA.2|alpha 2,3-ST 4|alpha 2,3-sialyltransferase IV|alpha-3-N-acetylneuraminyltransferase|beta-galactoside alpha-2,3-sialyltransferase 4|gal-NAc6S|gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase|sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)|sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase) |
| Swissprots | Q8NFG7 Q11206 O60497 A8K6B2 Q96QQ9 Q8N6A6 |
| Accessions | CAS91691 EAW67693 EAW67694 EAW67695 EAW67696 EAW67697 Q11206 AB009393 AF035249 AAC14162 AF516602 AAM66431 AF516603 AAM66432 AF516604 AAM66433 AF525084 AAM81378 AK021929 BAB13940 AK128605 AK291577 BAF84266 AK314738 BAG37279 AL520639 AL529887 AY040826 AAK93790 BC010645 AAH10645 BI259855 BP320415 CR456858 CAG33139 DA210431 DA841563 EU831802 ACE87320 EU831879 ACE86638 L23767 AAA16460 X74570 CAA52662 XM_011542959 XP_011541261 XM_011542960 XP_011541262 XM_011542961 XP_011541263 XM_011542962 XP_011541264 NM_001254757 NP_001241686 NM_001254758 NP_001241687 NM_001254759 NP_001241688 NM_006278 NP_006269 |
| Function | It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative. {ECO:0000269|PubMed:8611500}. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Highly expressed in adult placenta, ovary and testes. |
| Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |