| Gene Symbol | Ppp1r12a |
|---|---|
| Entrez Gene | 17931 |
| Alt Symbol | 1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, Mypt1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, regulatory (inhibitor) subunit 12A |
| Other Description | myosin phosphatase target subunit 1|myosin phosphatase, target subunit 1|myosin phosphatase-targeting subunit 1|protein phosphatase 1 regulatory subunit 12A |
| Swissprots | Q99NB6 Q8CBV2 Q05A74 Q9DBR7 |
| Accessions | BAB39108 EDL21699 EDL21700 EDL21702 EDL21703 Q9DBR7 AK004785 BAB23563 AK030460 AK035230 BAC28990 AK077739 AK139570 AK162199 BAE36787 AK182043 BC054076 BC125381 AAI25382 BC137630 AAI37631 XM_006513326 XP_006513389 XM_006513327 XP_006513390 XM_006513328 XP_006513391 XM_006513329 XP_006513392 NM_027892 NP_082168 |
| Function | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Note=Along actomyosin filaments and stress fibers. {ECO:0000250}. |
| Tissue Specificity | Expressed in striated and vascular smooth muscle, specificcally in type 2a fibers (at protein level). Expression levels are 20-30% higher in developed males than females (at protein level). {ECO:0000269|PubMed:20634291}. |
| Top Pathways | Focal adhesion, Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway |