| Gene Symbol |
ITGB1
|
| Entrez Gene |
3688
|
| Alt Symbol |
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
|
| Other Description |
glycoprotein IIa|integrin VLA-4 beta subunit|integrin beta-1|very late activation protein, beta polypeptide
|
| Swissprots |
D3DRY3 Q13090 Q29RW2 P78466 P05556 Q7Z3V1 D3DRY5 Q13089 Q14647 Q13091 A8K6N2 D3DRY4 Q13212 Q14622 P78467 D3DRX9 Q8WUM6
|
| Accessions |
AAA79832 AAA79833 AAA79834 AAA79835 EAW85948 EAW85949 EAW85950 EAW85951 EAW85952 EAW85953 EAW85954 EAW85955 EAW85956 EAW85957 EAW85958 EAW85959 EAW85960 P05556 AI261443 AK291697 BAF84386 AL710802 AM393197 CAL38075 BC020057 AAH20057 BC113901 AAI13902 BM791591 BM973433 BX537407 CAD97649 CX868374 CX871886 DA600874 DB063946 DB292597 DQ891069 ABM81995 DQ894251 ABM85177 M34189 AAA59182 M84237 AAA74402 U28252 AAA81366 XM_005252448 XP_005252505 NM_002211 NP_002202 NM_033668 NP_391988 NM_133376 NP_596867 NM_033666 NM_033667 NM_033669
|
| Function |
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may medi
|
| Subcellular Location |
Cell membrane {ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171}; Single- pass type I membrane protein {ECO:0000255}. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid- telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the s
|
| Tissue Specificity |
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non- proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). {ECO:0000269|PubMed:1551917, ECO:0000269|PubMed:2249781, ECO:0000269|PubMed:7544298, ECO:0000269|PubMed:7545396, ECO:0000269|P
|
| Top Pathways |
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pertussis, PI3K-Akt signaling pathway, Toxoplasmosis, Rap1 signaling pathway
|
![All lanes : Anti-Integrin beta 1 (phospho Y783) antibody [EP974(2)Y] (ab62337) at 1/100000 dilutionLane 1 : untreated U937 cell lysatesLane 2 : U937 cell lysates treated with pervanadateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP labeled at 1/2000 dilution](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_3/9132_Wb%2520int%2520beta%25201%2520phospho.jpg)
