| Gene Symbol |
pgant2
|
| Entrez Gene |
33556
|
| Alt Symbol |
CG3254, Dmel\CG3254, PGANT2
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
polypeptide GalNAc transferase 2
|
| Other Description |
CG3254-PA|CG3254-PB|pgant2-PA|pgant2-PB
|
| Swissprots |
Q7KU27 Q7YU21 Q9VQQ2 Q6WV19
|
| Accessions |
AAF51113 AAS64620 Q6WV19 NM_134929 NP_608773 NM_205903 NP_995625
|
| Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in developing oocytes and egg chambers. No expression observed during embryonic stages 9-11. During embryonic stages 12-13, specific expression is observed in the developing tracheal branches and brain. During embryonic stages 14-17, expression is restricted to the dorsal longitudinal trachea. In third instar larvae imaginal wing disk, expressed in clusters of cells in the presumptive pleura and notum. In eye- antennal imaginal disk, shows a very distinct band of expression at the morphogenetic furrow and weaker expression in the presumptive eye posterior to the furrow, no expression is detected in the presumptive antennal or head region anterior to the furrow. No expression observed in leg or haltere imaginal disks. {ECO:0000269|PubMed:12829714, ECO:0000269|PubMed:16251381}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|