| Gene Symbol |
ING3
|
| Entrez Gene |
54556
|
| Alt Symbol |
Eaf4, ING2, MEAF4, p47ING3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inhibitor of growth family, member 3
|
| Other Description |
inhibitor of growth protein 3
|
| Swissprots |
Q969G0 Q96DT4 Q7Z762 Q9P081 A8K790 Q567P3 Q9NXR8 Q9HC99 O60394 Q6GMT3
|
| Accessions |
AAQ93373 AAQ93374 EAW83546 EAW83547 EAW83548 EAW83549 Q9NXR8 AF074968 AAG12172 AF161419 AAF28979 AF180298 AAQ13674 AK000096 BAA90942 AK291905 BAF84594 AK293682 BAG57123 AL603623 CAC48260 AY007790 AAG23285 BC009776 AAH09776 BC009777 AAH09777 BC010851 AAH10851 BC062634 AAH62634 BC073865 AAH73865 BC093091 AAH93091 BC093689 AAH93689 BC101609 AAI01610 BC143316 AAI43317 BC146417 AAI46418 BC153171 AAI53172 BU677936 BU684039 CA442734 NM_019071 NP_061944 NM_198267 NP_938008 NM_198266
|
| Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:12545155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
|