| Gene Symbol | CTPS1 |
|---|---|
| Entrez Gene | 1503 |
| Alt Symbol | CTPS, IMD24 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CTP synthase 1 |
| Other Description | CTP synthetase 1|UTP--ammonia ligase 1|cytidine 5'-triphosphate synthetase|cytidine 5-prime triphosphate synthetase |
| Swissprots | B4DR64 Q96GK6 D3DPW1 P17812 Q5VW67 |
| Accessions | EAX07192 EAX07193 P17812 AI190299 AK130549 AK225899 AK297386 BAG59827 AK299122 BAG61176 AK303797 BAG64752 AK304817 BAH14260 BC009408 AAH09408 BQ642049 DA639348 DC313620 X52142 CAA36386 XM_005270536 XP_005270593 XM_006710390 XP_006710453 XM_006710391 XP_006710454 XM_011540821 XP_011539123 XM_011540822 XP_011539124 XR_946557 NM_001301237 NP_001288166 NM_001905 NP_001896 NR_125440 |
| Function | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:24870241}. |
| Top Pathways | Pyrimidine metabolism |