Gene Symbol | CTPS1 |
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Entrez Gene | 1503 |
Alt Symbol | CTPS, IMD24 |
Species | Human |
Gene Type | protein-coding |
Description | CTP synthase 1 |
Other Description | CTP synthetase 1|UTP--ammonia ligase 1|cytidine 5'-triphosphate synthetase|cytidine 5-prime triphosphate synthetase |
Swissprots | B4DR64 Q96GK6 D3DPW1 P17812 Q5VW67 |
Accessions | EAX07192 EAX07193 P17812 AI190299 AK130549 AK225899 AK297386 BAG59827 AK299122 BAG61176 AK303797 BAG64752 AK304817 BAH14260 BC009408 AAH09408 BQ642049 DA639348 DC313620 X52142 CAA36386 XM_005270536 XP_005270593 XM_006710390 XP_006710453 XM_006710391 XP_006710454 XM_011540821 XP_011539123 XM_011540822 XP_011539124 XR_946557 NM_001301237 NP_001288166 NM_001905 NP_001896 NR_125440 |
Function | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:24870241}. |
Top Pathways | Pyrimidine metabolism |
CTPS CRISPR/Cas9 KO Plasmid (h) - sc-403505 from Santa Cruz Biotechnology
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CTPS HDR Plasmid (h) - sc-403505-HDR from Santa Cruz Biotechnology
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CTPS Double Nickase Plasmid (h) - sc-403505-NIC from Santa Cruz Biotechnology
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CTPS Double Nickase Plasmid (h2) - sc-403505-NIC-2 from Santa Cruz Biotechnology
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CTPS CRISPR Activation Plasmid (h) - sc-403505-ACT from Santa Cruz Biotechnology
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CTPS CRISPR Activation Plasmid (h2) - sc-403505-ACT-2 from Santa Cruz Biotechnology
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CTPS Lentiviral Activation Particles (h) - sc-403505-LAC from Santa Cruz Biotechnology
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CTPS Lentiviral Activation Particles (h2) - sc-403505-LAC-2 from Santa Cruz Biotechnology
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CTPS1 siRNA (h) - sc-78858 from Santa Cruz Biotechnology
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CTPS1 shRNA Plasmid (h) - sc-78858-SH from Santa Cruz Biotechnology
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CTPS1 shRNA (h) Lentiviral Particles - sc-78858-V from Santa Cruz Biotechnology
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CTP synthase RNAi - H00001503-R01 from Novus Biologicals
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MISSION® esiRNA - EHU130661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6742 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6742 from Sigma-Aldrich
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CTPS1 siRNA (Human) - CRH1063 from Cohesion Biosciences
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CTPS1 - MBS8222466 from MyBioSource
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shRNA set against Human CTPS (NM_001905.2) - SHH271381 from Creative biogene
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shRNA set against Human CTPS(NM_001905.2) - SHG172027 from Creative biogene
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Human CTPS1 siRNA - orb261565 from Biorbyt
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CTPS1 shRNA Plasmid (Human) - CHH1063 from Cohesion Biosciences
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CTPS1 miRNA 3'UTR clone - MiUTR1H-02535 from Creative biogene
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