| Gene Symbol |
DHX9
|
| Entrez Gene |
1660
|
| Alt Symbol |
DDX9, LKP, NDH2, NDHII, RHA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAH (Asp-Glu-Ala-His) box helicase 9
|
| Other Description |
ATP-dependent RNA helicase A|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9|DEAH (Asp-Glu-Ala-His) box polypeptide 9|DEAH box protein 9|RNA helicase A|leukophysin|nuclear DNA helicase II
|
| Swissprots |
Q99556 Q12803 Q32Q22 Q05CI5 Q08211 Q5VY62 Q6PD69 B2RNV4
|
| Accessions |
EAW91137 EAW91138 Q08211 AA836637 AB451248 BAG70062 AB451372 BAG70186 AF086352 AK096582 BAG53328 AK130564 AK226102 AK308165 BC008773 AAH08773 BC014246 AAH14246 BC025245 AAH25245 BC032742 BC058896 AAH58896 BC071950 BC107881 AAI07882 BC137136 AAI37137 BC144494 DB002450 DB223823 DB285127 L13848 AAB48855 U03643 AAA03571 Y10658 CAA71668 NM_001357 NP_001348 NR_033302 NM_030588
|
| Function |
Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression. {ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:22190748}.
|
| Subcellular Location |
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.
|