GOSR1

Gene Symbol GOSR1
Entrez Gene 9527
Alt Symbol GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28
Species Human
Gene Type protein-coding
Description golgi SNAP receptor complex member 1
Other Description 28 kDa Golgi SNARE protein|28 kDa cis-Golgi SNARE p28|Golgi SNAP receptor complex member 1|Golgi SNARE 28 kDa|cis-golgi SNARE|golgi integral membrane protein 2
Swissprots O95249 J3KST5 O75392
Accessions AAK01856 EAW51229 EAW51230 EAW51231 O95249 AF047438 AAC39889 AF073926 AAD12945 AK000606 AK074298 AK128816 AK291381 BAF84070 AK298714 BAG60870 AL049346 BC012620 AAH12620 BC040072 BC040471 AAH40471 BE785872 BG654545 CB054624 XM_005258070 XP_005258127 XM_005258071 XP_005258128 XM_005258072 XP_005258129 NM_001007024 NP_001007025 NM_001007025 NP_001007026 NM_004871 NP_004862
Function Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.
Top Pathways SNARE interactions in vesicular transport

GOSR1 293T Cell Transient Overexpression Lysate(Denatured) - H00009527-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

GOSR1 overexpression lysate - LY423566 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

GOSR1 overexpression lysate - LY425197 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

GOSR1 293 Cell Lysate - 409964 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

GOSR1 Overexpression Lysate (Denatured) - H00009527-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
GOSR1 transfected lysate.

GOSR1 Overexpression Lysate (Native) - NBL1-11204 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: GOSR1 Overexpression Lysate (Adult Normal) [NBL1-11204] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GOSR1.

GOSR1 Over-expression Lysate Product - GWB-2B031F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human GOSR1 Knockdown Stable Cell Line - CSC-DC006459 from Creative biogene

Category Cell Line
Species Human
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