| Gene Symbol | PHF10 |
|---|---|
| Entrez Gene | 507648 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | PHD finger protein 10 |
| Other Description | BAF45a|BRG1-associated factor 45a |
| Swissprots | Q2T9V9 |
| Accessions | DAA25934 Q2T9V9 BC111243 AAI11244 NM_001038052 NP_001033141 |
| Function | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulatin |
| Subcellular Location | Nucleus {ECO:0000250}. |
PHD finger protein 10, ELISA Kit - MBS9322205 from MyBioSource
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Bovine PHF10 ELISA Kit - E093465 from Biobool
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