Gene Symbol | Prkdc |
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Entrez Gene | 19090 |
Alt Symbol | AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip |
Species | Mouse |
Gene Type | protein-coding |
Description | protein kinase, DNA activated, catalytic polypeptide |
Other Description | DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|doxorubicin nephropathy|severe combined immunodeficiency |
Swissprots | O88187 P97313 P97928 Q3V2W8 Q9Z341 Q307W9 E9QN15 Q8C2A7 |
Accessions | BAB91149 CAC42768 CAC42769 CAC42770 CAC42771 EDK97403 P97313 AB007544 BAA28873 AB011543 BAA28875 AK084827 BAE43387 AK088981 BAC40685 AK137732 AU019811 BC028664 D83786 BAA12115 D87521 BAA19566 DQ235257 ABB36568 DQ235258 ABB36569 U78157 AAB36939 U78158 AAB36940 XM_006521861 XP_006521924 XM_011245841 XP_011244143 XM_011245842 XP_011244144 NM_011159 NP_035289 |
Function | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat |
Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. |
Top Pathways | Cell cycle, Non-homologous end-joining |
DNAPK antibody (Thr2638) - 70R-33564 from Fitzgerald
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DNAPK antibody - 70R-31162 from Fitzgerald
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DNAPK antibody - 70R-33567 from Fitzgerald
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DNAPK antibody - 70R-33565 from Fitzgerald
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DNA-dependent protein kinase catalytic subunit antibody (Biotin) - orb240727 from Biorbyt
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DNAPK antibody (Ser2056) - 70R-33566 from Fitzgerald
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DNA-dependent protein kinase catalytic subunit Antibody - abx109732 from Abbexa
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PRKDC Antibody - abx114816 from Abbexa
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PRKDC Antibody (Biotin) - abx105350 from Abbexa
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PRKDC Antibody (FITC) - abx106769 from Abbexa
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PRKDC Antibody (HRP) - abx108188 from Abbexa
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DNA-PKcs / PRKDC / XRCC7 antibody - AP54881SU-N from Acris Antibodies
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DNA-dependent protein kinase catalytic subunit, Polyclonal Antibody - MBS1490722 from MyBioSource
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DNA-dependent protein kinase catalytic subunit, Polyclonal Antibody - MBS1489274 from MyBioSource
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DNA-dependent protein kinase catalytic subunit, Polyclonal Antibody - MBS1490304 from MyBioSource
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DNA-dependent protein kinase catalytic subunit, Polyclonal Antibody - MBS1491441 from MyBioSource
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PRKDC Antibody - CSB-PA018714GA01HU from Cusabio
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Rabbit anti-human DNA-dependent protein kinase catalytic subunit polyclonal Anti - CSB-PA018714HD01MO from Cusabio
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Rabbit anti-mouse DNA-dependent protein kinase catalytic subunit polyclonal Anti - CSB-PA018714HC01MO from Cusabio
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Rabbit anti-mouse DNA-dependent protein kinase catalytic subunit polyclonal Anti - CSB-PA018714HB01MO from Cusabio
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Rabbit anti-mouse DNA-dependent protein kinase catalytic subunit polyclonal Anti - CSB-PA018714HA01MO from Cusabio
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DNA-dependent protein kinase catalytic subunit... - pab0492 from Covalab
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Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) - PAK362Mu01 from Cloud-clone
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Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) - PAK362Mu02 from Cloud-clone
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DNA PKcs antibody - 70R-50261 from Fitzgerald
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