| Gene Symbol | Prkdc |
|---|---|
| Entrez Gene | 19090 |
| Alt Symbol | AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein kinase, DNA activated, catalytic polypeptide |
| Other Description | DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|doxorubicin nephropathy|severe combined immunodeficiency |
| Swissprots | O88187 P97313 P97928 Q3V2W8 Q9Z341 Q307W9 E9QN15 Q8C2A7 |
| Accessions | BAB91149 CAC42768 CAC42769 CAC42770 CAC42771 EDK97403 P97313 AB007544 BAA28873 AB011543 BAA28875 AK084827 BAE43387 AK088981 BAC40685 AK137732 AU019811 BC028664 D83786 BAA12115 D87521 BAA19566 DQ235257 ABB36568 DQ235258 ABB36569 U78157 AAB36939 U78158 AAB36940 XM_006521861 XP_006521924 XM_011245841 XP_011244143 XM_011245842 XP_011244144 NM_011159 NP_035289 |
| Function | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat |
| Subcellular Location | Nucleus. Nucleus, nucleolus {ECO:0000250}. |
| Top Pathways | Cell cycle, Non-homologous end-joining |