Gene Symbol | PDE4C |
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Entrez Gene | 5143 |
Alt Symbol | DPDE1 |
Species | Human |
Gene Type | protein-coding |
Description | phosphodiesterase 4C, cAMP-specific |
Other Description | PDE21|cAMP-specific 3',5'-cyclic phosphodiesterase 4C|phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)|phosphodiesterase E1 dunce homolog |
Swissprots | Q9UN44 Q9UN45 Q08493 Q9UPJ6 Q9UN46 B3KTC4 |
Accessions | AAC83047 AAC83048 AAC83049 AAC83050 AAC83051 AAD47053 AAD47054 AAD47055 AAF67386 EAW84675 EAW84676 EAW84677 EAW84678 EAW84679 Q08493 AI051127 AK295050 BAH11959 AK300888 BAH13367 AK300983 BAH13388 AY429555 AY429556 AY429557 AY429558 BC109067 AAI09068 BC109068 AAI09069 DB313915 L20968 AAA03591 U66346 AAB96875 U66347 AAB96876 U66348 AAB96877 U66349 AAB96878 U88712 AAC51915 U88713 AAC51916 Z46632 CAA86601 XM_011528056 XP_011526358 XM_011528057 XP_011526359 XM_011528058 XP_011526360 NM_000923 NP_000914 NM_001098818 NP_001092288 NM_001098819 NP_001092289 NR_040546 |
Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:17727341}. |
Subcellular Location | Cell projection, cilium {ECO:0000250}. |
Tissue Specificity | Expressed in various tissues but not in cells of the immune system. |
Top Pathways | Morphine addiction, cAMP signaling pathway, Purine metabolism |
PDE4C CRISPR/Cas9 KO Plasmid (h) - sc-404832 from Santa Cruz Biotechnology
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PDE4C HDR Plasmid (h) - sc-404832-HDR from Santa Cruz Biotechnology
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PDE4C Double Nickase Plasmid (h) - sc-404832-NIC from Santa Cruz Biotechnology
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PDE4C Double Nickase Plasmid (h2) - sc-404832-NIC-2 from Santa Cruz Biotechnology
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PDE4C CRISPR Activation Plasmid (h) - sc-404832-ACT from Santa Cruz Biotechnology
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PDE4C CRISPR Activation Plasmid (h2) - sc-404832-ACT-2 from Santa Cruz Biotechnology
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PDE4C Lentiviral Activation Particles (h) - sc-404832-LAC from Santa Cruz Biotechnology
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PDE4C Lentiviral Activation Particles (h2) - sc-404832-LAC-2 from Santa Cruz Biotechnology
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PDE4C siRNA (h) - sc-41601 from Santa Cruz Biotechnology
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PDE4C shRNA Plasmid (h) - sc-41601-SH from Santa Cruz Biotechnology
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PDE4C shRNA (h) Lentiviral Particles - sc-41601-V from Santa Cruz Biotechnology
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PDE4C RNAi - H00005143-R01 from Novus Biologicals
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PDE4C RNAi - H00005143-R02 from Novus Biologicals
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MISSION® esiRNA - EHU060201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16538 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16538 from Sigma-Aldrich
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PDE4C siRNA (Human) - CRH3423 from Cohesion Biosciences
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PDE4C RNAi - H00005143-R03 from Novus Biologicals
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shRNA set against Human PDE4C (NM_000923.4) - SHH372452 from Creative biogene
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Human PDE4C siRNA - orb263925 from Biorbyt
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PDE4C shRNA Plasmid (Human) - CHH3423 from Cohesion Biosciences
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