| Gene Symbol |
FMNL1
|
| Entrez Gene |
752
|
| Alt Symbol |
C17orf1, C17orf1B, FHOD4, FMNL, KW-13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
formin-like 1
|
| Other Description |
CLL-associated antigen KW-13|formin-like protein 1|leukocyte formin
|
| Swissprots |
Q96H10 Q86UH1 Q6DKG5 Q8TDH1 Q8N671 Q6IBP3 D2DGW2 O95466
|
| Accessions |
EAW51534 EAW51535 EAW51536 EAW51537 EAW51538 O95466 AF432213 AAL99920 AJ008112 CAA07870 AJ008113 AJ008114 AJ008115 AJ008116 AJ008117 AJ008118 AJ008119 AJ008120 AJ008121 AJ008122 AJ008123 AJ008124 AJ008125 AJ008126 AJ008127 AJ008128 AJ008129 AJ008130 AJ008131 AJ008132 AJ008133 AK131091 BAC85141 AY278319 AAP32476 BC001710 AAH01710 BC009000 AAH09000 BC021906 AAH21906 BC042925 BC064572 BC073988 AAH73988 BC111564 AAI11565 CR456759 CAG33040 FJ534522 ACR19333 XM_006722062 XP_006722125 XM_006722063 XP_006722126 XM_006722064 XP_006722127 XM_006722065 XP_006722128 XM_006722066 XP_006722129 XM_006722069 XP_006722132 XM_006722070 XP_006722133 XM_011525179 XP_011523481 XM_011525180 XP_011523482 XM_011525181 XP_011523483 XM_011525182 XP_011523484 NM_005892 NP_005883
|
| Function |
May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19815554}; Lipid-anchor {ECO:0000269|PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|