TOP3B

Gene Symbol	TOP3B
Entrez Gene	8940
Alt Symbol	TOP3B1
Species	Human
Gene Type	protein-coding
Description	topoisomerase (DNA) III beta
Other Description	DNA topoisomerase 3-beta-1|DNA topoisomerase III beta-1|topoisomerase III beta
Swissprots	A0M8Q3 O95985 Q9BUP5
Accessions	BAA20009 EAW59487 EAW59488 EAW59489 EAW59490 EAW59491 O95985 AF017146 AAD01614 AF053082 AAD15791 AF125216 AAD29670 AK096695 BAG53351 AK290997 BAF83686 AK304681 BAG65452 AK304709 BAG65474 AL833505 BC002432 AAH02432 BQ270362 CR456596 CAG30482 CU013196 CAK54627 CU013484 CAK54926 DA025312 XM_005261811 XP_005261868 XM_005261813 XP_005261870 XM_006724349 XP_006724412 XM_006724350 XP_006724413 XM_011530482 XP_011528784 XM_011530483 XP_011528785 XM_011530484 XP_011528786 XR_244395 XR_937945 XR_937946 NM_001282112 NP_001269041 NM_001282113 NP_001269042 NM_003935 NP_003926
Function	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. {ECO:0000250}.
Tissue Specificity	Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas. {ECO:0000269|PubMed:9927731}.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TOP3B full length protein - ab160273 from Abcam Category Protein Source Wheat germ Species Human

Human TOP3B peptide - ab199552 from Abcam Category Peptide Species Human

TOP3B Antibody Blocking Peptide - LS-E4459 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Topo III beta Protein - H00008940-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TOP3B-Antibody-C-term-Blocking-Peptide - BP16775b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TOP3B peptide - orb218200 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog

TOP3B - H00008940-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TOP3B - H00008940-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TOP3B fusion protein - Ag14115 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TOP3B fusion protein - Ag14336 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TOP3B, GST-tagged - TOP3B-3353H from Creative Biomart Category Protein Source E.coli Species Human

Topoisomerase 3 beta1 Blocking Peptide - CBP2337 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig

Topo IIIβ-1 (Q84) Peptide - BS1908P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA topoisomerase 3-beta-1(TOP3B) ,partial - CSB-YP024063HU CSB-EP024063HU CSB-BP024063HU CSB-MP024063HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TOP3B Protein - abx163590 from Abbexa Category Protein Species Human, Rat

Recombinant Topoisomerase III Beta (TOP3b) - RPD799Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

TOP3B Peptide, Human - M34GP16437H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Topoisomerase III Beta (TOP3b) - RPU51293 from Biomatik Category Protein Prices $168.00, $344.00, $526.00, $657.04 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

TOP3B Recombinant Protein (OPCD00469) - OPCD00469 from Aviva Systems Biology Category Protein Source E.coli Species Human

DNA topoisomerase 3-beta-1 (TOP3B), partial, Recombinant Protein - MBS1179131 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Topo III beta Recombinant Protein Antigen - NBP2-57658PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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