| Gene Symbol | Galnt3 |
|---|---|
| Entrez Gene | 14425 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 |
| Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3|galNAc-T3|polypeptide GalNAc transferase 3|polypeptide N-acetylgalactosaminyltransferase 3|pp-GaNTase 3|ppGaNTase-T3|protein-UDP acetylgalactosaminyltransferase 3 |
| Swissprots | Q80V55 P70419 Q3UXL2 |
| Accessions | EDL27008 P70419 AK007135 AK019995 AK087219 AK135489 BAE22551 AV274239 BC003765 BC043331 AAH43331 U70538 AAB09579 XR_374409 NM_015736 NP_056551 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Glycosylates FGF23 (By similarity). Probably glycosylates fibronectin in vivo. May be involved in phosphate homeostasis. {ECO:0000250}. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in the reproductive tract, principally in the testis and uterus, and to a lesser degree in the cervix with only trace levels in the ovary. Also expressed at high level in sublingual gland, stomach and colon, with more moderate amounts present in the submandibular and parotid gland as well as the kidney. {ECO:0000269|PubMed:8912633}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T3 CRISPR/Cas9 KO Plasmid (m) - sc-420477 from Santa Cruz Biotechnology
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GalNAc-T3 HDR Plasmid (m) - sc-420477-HDR from Santa Cruz Biotechnology
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GalNAc-T3 Double Nickase Plasmid (m) - sc-420477-NIC from Santa Cruz Biotechnology
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GalNAc-T3 Double Nickase Plasmid (m2) - sc-420477-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T3 CRISPR Activation Plasmid (m) - sc-420477-ACT from Santa Cruz Biotechnology
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GalNAc-T3 CRISPR Activation Plasmid (m2) - sc-420477-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T3 Lentiviral Activation Particles (m) - sc-420477-LAC from Santa Cruz Biotechnology
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GalNAc-T3 Lentiviral Activation Particles (m2) - sc-420477-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T3 siRNA (m) - sc-75097 from Santa Cruz Biotechnology
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GalNAc-T3 shRNA Plasmid (m) - sc-75097-SH from Santa Cruz Biotechnology
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GalNAc-T3 shRNA (m) Lentiviral Particles - sc-75097-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU045481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31706 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31706 from Sigma-Aldrich
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GALNT3 siRNA (Mouse) - CRM1484 from Cohesion Biosciences
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GALNT3 - MBS8223314 from MyBioSource
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shRNA set against Mouse GALNT3 (NM_015736.2) - SHH299045 from Creative biogene
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shRNA set against Mouse Galnt3(NM_015736.2) - SHH076241 from Creative biogene
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GALNT3 shRNA Plasmid (Mouse) - CHM1484 from Cohesion Biosciences
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GALNT3 miRNA 3'UTR clone - MiUTR1M-04914 from Creative biogene
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