| Gene Symbol |
NFAT5
|
| Entrez Gene |
10725
|
| Alt Symbol |
NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of activated T-cells 5, tonicity-responsive
|
| Other Description |
NFAT-like protein 1|T-cell transcription factor NFAT5|TonE-binding protein|glutamine rich protein H65|nuclear factor of activated T-cells 5|osmotic response element-binding protein|tonicity-responsive enhancer-binding protein
|
| Swissprots |
O95693 A2RRB4 Q96QH3 Q9UN18 A6H8V5 Q7LA65 Q969Q8 O94916 E9PHR7
|
| Accessions |
EAW83277 EAW83278 EAW83279 EAW83280 EAW83281 O94916 AA291524 AA321843 AB020634 BAA74850 AF089824 AAD18136 AF134870 AAD38360 AF163836 AAD48441 AF346509 AAK91166 AJ005683 AJ005684 AJ243298 CAC42764 AJ243299 CAC42765 AK000312 AK001067 BC089395 BC131509 AAI31510 BC146765 AAI46766 BE737032 HG508222 U80231 AAD00352 Z97016 CAB09693 XM_006721125 XP_006721188 XM_011522817 XP_011521119 XM_011522818 XP_011521120 XM_011522819 XP_011521121 XM_011522820 XP_011521122 XM_011522821 XP_011521123 XM_011522822 XP_011521124 NM_001113178 NP_001106649 NM_006599 NP_006590 NM_138713 NP_619727 NM_138714 NP_619728 NM_173214 NP_775321 NM_173215 NP_775322
|
| Function |
Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear distribution increases under hypertonic conditions. {ECO:0000250}.
|
| Tissue Specificity |
Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.
|