Uba1

Gene Symbol Uba1
Entrez Gene 22201
Alt Symbol A1S9, Sbx, Ube-1, Ube1x
Species Mouse
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 1
Other Description ubiquitin-activating enzyme E1, Chr X|ubiquitin-like modifier-activating enzyme 1
Swissprots P31253 A6H6S6 Q02053 Q542H8
Accessions AAC52169 EDL00743 Q02053 AK081808 AK088057 BAC40121 AK088528 BAC40405 AK143416 BAE25369 AK171667 BAE42599 AK176944 AK177712 AK177725 AK178020 AK178664 AK178731 AK179147 AK179498 AK180642 AK181308 AK181359 AK182461 AK182527 AK185205 AK185591 AK185680 AK186400 AK186677 AK188893 AK188980 AK189333 AK191964 AK192165 AK193933 AK194086 AK194187 AK194291 AK194651 AK194691 AK194752 AK195016 AK195106 AK195920 AK195971 AK197186 AK197490 AK197943 AK199340 AK199544 AK199667 AK199754 AK199948 AK200836 AK201099 AK201652 AK202271 AK202478 AK204473 AK204546 AK204860 AK205285 AK205612 AK205753 AK205902 AK205991 AK206372 AK206443 AK207091 AK207789 AK208897 AK209084 AK209874 AK210112 AK210744 AK210948 AK211490 AK211788 AK213246 AK215149 AK215450 AK217264 AK217817 AK219140 AK219193 AK219392 AK219712 AK219868 AK219938 BB858760 BC058630 AAH58630 BC138200 AAI38201 BC145984 AAI45985 BY004827 BY316912 D10576 BAA01433 S70396 AAP19638 X62580 CAA44465 NM_001136085 NP_001129557 NM_001276316 NP_001263245 NM_001276317 NP_001263246 NM_009457 NP_033483
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. In testis, expressed in A spermatogonia and spermatids but at very low levels in pachytene spermatocytes. {ECO:0000269|PubMed:8948595}.
Top Pathways Ubiquitin mediated proteolysis

UBE1 CRISPR/Cas9 KO Plasmid (m) - sc-423581 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 HDR Plasmid (m) - sc-423581-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 Double Nickase Plasmid (m) - sc-423581-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 Double Nickase Plasmid (m2) - sc-423581-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 CRISPR Activation Plasmid (m) - sc-423581-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 CRISPR Activation Plasmid (m2) - sc-423581-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 Lentiviral Activation Particles (m) - sc-423581-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 Lentiviral Activation Particles (m2) - sc-423581-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

UBE1 siRNA (m) - sc-61751 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

UBE1 shRNA Plasmid (m) - sc-61751-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

UBE1 shRNA (m) Lentiviral Particles - sc-61751-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU024601 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN43779 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43779 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UBA1 siRNA (Mouse) - CRM4313 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse UBA1 (NM_009457.3) - SHH438640 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse UBA1 siRNA - orb283789 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

UBA1 shRNA Plasmid (Mouse) - CHM4313 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

UBA1 miRNA 3'UTR clone - MiUTR1M-12375 from Creative biogene

Species Reactivities Mouse
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