USH2A

Gene Symbol USH2A
Entrez Gene 7399
Alt Symbol RP39, US2, USH2, dJ1111A8.1
Species Human
Gene Type protein-coding
Description Usher syndrome 2A (autosomal recessive, mild)
Other Description usher syndrome type IIa protein|usher syndrome type-2A protein|usherin
Swissprots Q9NS27 O75445 Q5VVM9 Q6S362
Accessions AAF75819 O75445 AA883599 AF055580 AAC23748 AY481573 AAS47698 NM_007123 NP_009054 NM_206933 NP_996816
Function Involved in hearing and vision.
Subcellular Location Cell projection, stereocilium membrane {ECO:0000269|PubMed:14676276}; Single-pass type I membrane protein {ECO:0000269|PubMed:14676276}. Note=Probable component of the interstereocilia ankle links in the inner ear sensory cells.
Tissue Specificity Present in the basement membrane of many, but not all tissues. Expressed in retina, cochlea, small and large intestine, pancreas, bladder, prostate, esophagus, trachea, thymus, salivary glands, placenta, ovary, fallopian tube, uterus and testis. Absent in many other tissues such as heart, lung, liver, kidney and brain. In the retina, it is present in the basement membranes in the Bruch's layer choroid capillary basement membranes, where it localizes just beneath the retinal pigment epithelial cells (at protein level). Weakly expressed. Isoform 2 is expressed in fetal eye, cochlea and heart, and at very low level in brain, CNS, intestine, skeleton, tongue, kidney and lung. Isoform 2 is not expressed in stomach and liver. In adult tissues, isoform 2 is expressed in neural retina and testis, and at low level in brain, heart, kidney and liver. Isoform 1 displays a similar pattern of expression but is expressed at very low level in fetal cochlea. {ECO:0000269|PubMed:11788194, ECO:0000269|Pu

Usherin CRISPR/Cas9 KO Plasmid (h) - sc-409699 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin HDR Plasmid (h) - sc-409699-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin Double Nickase Plasmid (h) - sc-409699-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin Double Nickase Plasmid (h2) - sc-409699-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin CRISPR Activation Plasmid (h) - sc-409699-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin CRISPR Activation Plasmid (h2) - sc-409699-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin Lentiviral Activation Particles (h) - sc-409699-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin Lentiviral Activation Particles (h2) - sc-409699-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Usherin siRNA (h) - sc-61762 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Usherin shRNA Plasmid (h) - sc-61762-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Usherin shRNA (h) Lentiviral Particles - sc-61762-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN22551 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

USH2A siRNA (Human) - CRH5060 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USH2A - MBS8212181 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human USH2A (NM_007123.5) - SHH441141 from Creative biogene

Category siRNA
Species Reactivities Human

Human USH2A siRNA - orb265562 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USH2A shRNA Plasmid (Human) - CHH5060 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USH2A miRNA 3'UTR clone - MiUTR4H-TG09699 from Creative biogene

Species Reactivities Human
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