Gene Symbol |
FCRLA
|
Entrez Gene |
84824
|
Alt Symbol |
FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
Fc receptor-like A
|
Other Description |
Fc receptor homolog expressed in B cells (FREB)|Fc receptor related protein X|Fc receptor-like and mucin-like 1|fc receptor homolog expressed in B-cells|fc receptor-like and mucin-like protein 1|fc receptor-like protein|fc receptor-related protein X
|
Swissprots |
Q8NEW4 Q96PJ0 A0N0M1 A6NL20 Q5VXA1 Q5VXB1 F5H720 Q96PC6 Q96PJ4 F8W743 A6NC03 Q96PJ1 Q5VXA3 G3V1J2 Q9BR57 Q7L513 Q5VXA4 Q5VXA2 Q96PJ2 Q5VXB0 Q8WXH3
|
Accessions |
ABK41912 EAW90683 EAW90684 EAW90685 EAW90686 EAW90687 EAW90688 EAW90689 Q7L513 AF329489 AAL23899 AF329491 AAL23901 AF329493 AAL23903 AF329494 AAL23904 AF329495 AAL23905 AF390036 AAL27307 AF426461 AAL58111 AF531423 AAM97591 AY091642 AAM13980 AY358348 AAQ88714 BC006521 AAH06521 BM471887 BX112608 BX649184 CAE46202 DQ893274 ABM84200 DQ896605 ABM87604 XM_006711581 XP_006711644 XM_011510064 XP_011508366 XM_011510065 XP_011508367 XM_011510066 XP_011508368 NM_001184866 NP_001171795 NM_001184867 NP_001171796 NM_001184870 NP_001171799 NM_001184871 NP_001171800 NM_001184872 NP_001171801 NM_001184873 NP_001171802 NM_032738 NP_116127
|
Function |
May be implicated in B-cell differentiation and lymphomagenesis. {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275}.
|
Subcellular Location |
Secreted {ECO:0000305}. Cytoplasm.
|
Tissue Specificity |
Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes. {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:12202404, ECO:0000269|PubMed:15551350}.
|