SEPT9
| Gene Symbol | SEPT9 |
|---|---|
| Entrez Gene | 10801 |
| Alt Symbol | AF17q25, MSF, MSF1, NAPB, PNUTL4, SINT1, SeptD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | septin 9 |
| Other Description | MLL septin-like fusion protein MSF-A|Ov/Br septin|ovarian/breast septin|septin D1|septin-9 |
| Swissprots | Q9UG40 Q96QF3 B4DTL9 Q96QF4 B4E274 B4E0N2 Q9Y5W4 Q9UHD8 B7Z654 A8K2V3 Q96QF5 Q9HA04 B3KPM0 |
| Accessions | EAW89461 EAW89462 EAW89463 EAW89464 EAW89465 EAW89466 EAW89467 EAW89468 Q9UHD8 AA523782 AB023208 BAA76835 AF123052 AAD39749 AF142408 AAG27919 AF142569 AAG27922 AF189712 AAF23373 AF189713 AAF23374 AJ312319 CAC42221 AJ312320 CAC42222 AJ312321 CAC42223 AJ312322 CAC42224 AJ312323 CAC42225 AK022493 BAB14057 AK056495 BAG51732 AK290368 BAF83057 AK299828 BAH13140 AK300268 BAG62029 AK300270 BAG62031 AK303449 BAG64494 AK304143 BAG65036 AK316473 BAH14844 AL080131 CAB45728 BC018877 BC021192 AAH21192 BC054004 AAH54004 BC064642 BC114550 AAI14551 BC128416 AAI28417 BQ279153 BT007215 AAP35879 CN393537 DA234895 DB007851 DB148645 DC307336 DC410238 DQ890623 ABM92240 DQ893792 ABM84718 XM_005256962 XP_005257019 XM_006721643 XP_006721706 XM_006721644 XP_006721707 XM_011524204 XP_011522506 XM_011524205 XP_011522507 XM_011524206 XP_011522508 XM_011524207 XP_011522509 XM_011524208 XP_011522510 XM_011524209 XP_011522511 NM_001113491 NP_001106963 NM_001113492 NP_001106964 NM_001113493 NP_001106965 NM_001113494 NP_001106966 NM_001113495 NP_001106967 NM_001113496 NP_001106968 NM_001293695 NP_001280624 NM_001293696 NP_001280625 NM_001293697 NP_001280626 NM_001293698 NP_001280627 NM_006640 NP_006631 |
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:17922164}. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. |
| Tissue Specificity | Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues. {ECO:0000269|PubMed:10339604, ECO:0000269|PubMed:10673329, ECO:0000269|PubMed:11593400, ECO:0000269|PubMed:15915442}. |
| Top Pathways | Bacterial invasion of epithelial cells |
Septin 9 CRISPR/Cas9 KO Plasmid (h) - sc-403987 from Santa Cruz Biotechnology
|
||||||||
Septin 9 HDR Plasmid (h) - sc-403987-HDR from Santa Cruz Biotechnology
|
||||||||
Septin 9 Double Nickase Plasmid (h) - sc-403987-NIC from Santa Cruz Biotechnology
|
||||||||
Septin 9 Double Nickase Plasmid (h2) - sc-403987-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Septin 9 CRISPR Activation Plasmid (h) - sc-403987-ACT from Santa Cruz Biotechnology
|
||||||||
Septin 9 CRISPR Activation Plasmid (h2) - sc-403987-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Septin 9 Lentiviral Activation Particles (h) - sc-403987-LAC from Santa Cruz Biotechnology
|
||||||||
Septin 9 Lentiviral Activation Particles (h2) - sc-403987-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Septin 9 siRNA (h) - sc-61532 from Santa Cruz Biotechnology
|
||||||||
Septin 9 shRNA Plasmid (h) - sc-61532-SH from Santa Cruz Biotechnology
|
||||||||
Septin 9 shRNA (h) Lentiviral Particles - sc-61532-V from Santa Cruz Biotechnology
|
||||||||
Septin-9 RNAi - H00010801-R02 from Novus Biologicals
|
||||||||
Septin-9 RNAi - H00010801-R07 from Novus Biologicals
|
||||||||
Septin-9 RNAi - H00010801-R05 from Novus Biologicals
|
||||||||
Septin-9 RNAi - H00010801-R01 from Novus Biologicals
|
||||||||
Septin-9 RNAi - H00010801-R06 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU062441 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19112 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19112 from Sigma-Aldrich
|
||||||||
SEPT9 siRNA (Human) - CRH7361 from Cohesion Biosciences
|
||||||||
Septin-9 RNAi - H00010801-R04 from Novus Biologicals
|
||||||||
Septin-9 RNAi - H00010801-R03 from Novus Biologicals
|
||||||||
SEPT9 - MBS8240114 from MyBioSource
|
||||||||
shRNA set against Human SEPT9(NM_006640.4) - SHH221334 from Creative biogene
|
||||||||
Human SEPT9 siRNA - orb267863 from Biorbyt
|