| Gene Symbol |
Tcf23
|
| Entrez Gene |
69852
|
| Alt Symbol |
2010002O16Rik, Out, bHLHa24
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 23
|
| Other Description |
TCF-23|basic helix-loop-helix transcription factor OUT|ovary, uterus and testis protein
|
| Swissprots |
Q9JLR5
|
| Accessions |
BAB69473 EDL37319 Q9JLR5 AF142405 AAF31168 AK008056 AK030277 BAC26873 AK030297 BAC26885 BC119346 AAI19347 BC120609 AAI20610 XM_006504095 XP_006504158 XM_006504096 XP_006504159 NM_053085 NP_444315
|
| Function |
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis. {ECO:0000269|PubMed:10652346}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:10652346}.
|
| Tissue Specificity |
Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen. {ECO:0000269|PubMed:10652346}.
|