PSEN1

Gene Symbol	PSEN1
Entrez Gene	5663
Alt Symbol	AD3, FAD, PS-1, PS1, S182
Species	Human
Gene Type	protein-coding
Description	presenilin 1
Other Description	presenilin-1
Swissprots	P49768 Q96P33 Q14762 Q15719 B2R6D3 Q9UIF0 O95465 Q15720
Accessions	AAB46371 AAC97960 AAF19253 AAF19254 BAA20883 BAD30017 CAC88544 CAC88578 CDH92546 EAW81091 EAW81092 EAW81093 EAW81094 EAW81095 EAW81096 EAW81097 P49768 AF416717 AAL16811 AJ008005 CAA07825 AK094186 AK094256 AK122722 AK223173 BAD96893 AK303876 BAH14071 AK312531 BAG35430 AW069286 BC002708 BC011729 AAH11729 DA670846 DB075605 DB203403 HQ447260 ADQ31747 L42110 AAB46416 L76517 AAB46370 U40379 AAB05894 U40380 AAB05895 XM_005267864 XP_005267921 XM_005267866 XP_005267923 XM_011536971 XP_011535273 XM_011536972 XP_011535274 XM_011536973 XP_011535275 XM_011536974 XP_011535276 NM_000021 NP_000012 NM_007318 NP_015557 NM_007319
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. {ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11226248, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils.
Tissue Specificity	Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. {ECO:0000269|PubMed:11987239, ECO:0000269|PubMed:8574969}.
Top Pathways	Wnt signaling pathway, Notch signaling pathway, Alzheimer's disease, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Presenilin 1 peptide - ab49413 from Abcam Category Peptide Species Human

Human Presenilin 1 peptide - ab71179 from Abcam Category Peptide

Human Presenilin 1 peptide - ab71180 from Abcam Category Peptide

Human Presenilin 1 protein fragment - ab114286 from Abcam Category Protein Source Wheat germ Species Human

PSEN1 / Presenilin 1 Antibody Blocking Peptide - LS-E16240 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSEN1 / Presenilin 1 Antibody Blocking Peptide - LS-E8142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSEN1 / Presenilin 1 Antibody Blocking Peptide - LS-E21566 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSEN1 / Presenilin 1 Antibody Blocking Peptide - LS-E30343 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Presenilin-1 Protein - H00005663-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Presenilin-1 Blocking Peptide - NBP1-76792PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Presenilin-1 Peptide - P1839 from Novus Biologicals Category Peptide Species Human

Presenilin-12-PSEN1PSEN2-Antibody-C-term-Blocking-peptide - BP6304b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Presenilin-1-PSEN1-Antibody-C-term-Blocking-peptide - BP6231a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Presenilin-1-349-361 - SP2742a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

presenilin-1 protein - orb197677 from Biorbyt Category Protein Prices $306.00, $493.00, $638.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Presenilin 1 peptide - orb72134 from Biorbyt Category Peptide Prices $417.00 Sizes 1 mg Source Synthetic, sequence 14 AQMSEDNHLSNTVRSQNDNR 33

Presenilin 1 Blocking Peptide - 33R-9260 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSEN1 Blocking Peptide - 33R-2422 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Presenilin 1 Blocking Peptide - abx063152 from Abbexa Category Peptide Species Human, Monkey

Presenilin-1 Peptide Protein - abx060910 from Abbexa Category Peptide

Presenilin-1 - H00005663-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Presenilin-1 - H00005663-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Presenilin-1 control peptide - AP10278CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Presenilin-1 control peptide - AP10279CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Presenilin-1 Control Peptide - AP30692CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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