| Gene Symbol |
RNASEH2B
|
| Entrez Gene |
79621
|
| Alt Symbol |
AGS2, DLEU8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease H2, subunit B
|
| Other Description |
Aicardi-Goutieres syndrome 2 protein|RNase H2 subunit B|deleted in lymphocytic leukemia 8|ribonuclease H2 subunit B|ribonuclease HI subunit B
|
| Swissprots |
Q6PK48 G3XAJ1 Q5TBB1 Q9HAF7 Q05DR2
|
| Accessions |
EAX08863 EAX08864 Q5TBB1 AK021774 BAB13892 AK022667 AK124228 AK223340 BAD97060 AY764036 AAX13343 BC001397 AAH01397 BC005088 AAH05088 BC007332 AAH07332 BC010174 AAH10174 BC036744 AAH36744 BI837927 BX328027 BX330672 BX382357 CA309004 DB221997 DT216141 JF432504 ADZ15721 XM_005266524 XP_005266581 XM_005266525 XP_005266582 XM_006719867 XP_006719930 XM_011535229 XP_011533531 XM_011535230 XP_011533532 XM_011535231 XP_011533533 XM_011535232 XP_011533534 XM_011535233 XP_011533535 XM_011535234 XP_011533536 NM_001142279 NP_001135751 NM_024570 NP_078846
|
| Function |
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:16845400}.
|
| Top Pathways |
DNA replication
|
![Western Blot: RNASEH2B Overexpression Lysate (Adult Normal) [NBP2-06319] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNASEH2B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17070_RNASEH2B%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06319-img0001.jpg)