| Gene Symbol |
SFMBT1
|
| Entrez Gene |
51460
|
| Alt Symbol |
RU1, SFMBT, hSFMBT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Scm-like with four mbt domains 1
|
| Other Description |
Scm-related gene containing four mbt domains|Scm-related gene product containing four mbt domains|renal ubiquitous protein 1|scm-like with four MBT domains protein 1
|
| Swissprots |
Q96C73 Q402F7 Q9UHJ3 Q9Y4Q9
|
| Accessions |
EAW65271 EAW65272 EAW65273 Q9UHJ3 AB189472 BAE43835 AF168132 AAF19794 AI206996 AK313965 BAG36680 AL080140 CAB45734 AL523328 BC014614 AAH14614 BG717319 BG723139 BM560104 BU553665 CR981845 DB064119 DB070525 DB081417 DB085221 DQ892861 ABM83787 DQ896110 ABM87109 XM_005265221 XP_005265278 XM_006713203 XP_006713266 XM_006713204 XP_006713267 XM_011533824 XP_011532126 XM_011533825 XP_011532127 NM_016329 NP_057413 NM_001005158 NM_001005159
|
| Function |
Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. {ECO:0000269|PubMed:17599839, ECO:0000269|PubMed:23349461, ECO:0000269|PubMed:23592795}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17599839}.
|
| Tissue Specificity |
Expressed in all cell lines and normal tissues tested, including the thymus. {ECO:0000269|PubMed:10661410}.
|