Gene Symbol | FCER1G |
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Entrez Gene | 2207 |
Alt Symbol | FCRG |
Species | Human |
Gene Type | protein-coding |
Description | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide |
Other Description | Fc receptor gamma-chain|fc-epsilon RI-gamma|fcRgamma|fceRI gamma|high affinity immunoglobulin epsilon receptor subunit gamma|immunoglobulin E receptor, high affinity, gamma chain |
Swissprots | P30273 Q5VTW4 |
Accessions | CBK51078 CCF76977 EAW52623 EAW52624 P30273 AK307102 BC033872 AAH33872 DQ890782 ABM81708 EU176502 ABW03303 M33195 AAA35828 NM_004106 NP_004097 |
Function | Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. {ECO:0000269|PubMed:8611682}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}. |
Top Pathways | Natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, Asthma, Tuberculosis, Sphingolipid signaling pathway |
Fc ε RIγ siRNA (h) - sc-45267 from Santa Cruz Biotechnology
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Fc ε RIγ shRNA Plasmid (h) - sc-45267-SH from Santa Cruz Biotechnology
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Fc ε RIγ shRNA (h) Lentiviral Particles - sc-45267-V from Santa Cruz Biotechnology
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FCER1G RNAi - H00002207-R02 from Novus Biologicals
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MISSION® esiRNA - EHU055461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8582 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8582 from Sigma-Aldrich
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FCER1G siRNA (Human) - CRH1542 from Cohesion Biosciences
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FCER1G - MBS828968 from MyBioSource
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shRNA set against Human FCER1G (NM_004106.1) - SHH293633 from Creative biogene
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shRNA set against Human FCER1G(NM_004106.1) - SHH054047 from Creative biogene
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Human FCER1G siRNA - orb262044 from Biorbyt
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FCER1G shRNA Plasmid (Human) - CHH1542 from Cohesion Biosciences
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FCER1G miRNA 3'UTR clone - MiUTR1H-03591 from Creative biogene
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