| Gene Symbol |
ACKR2
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| Entrez Gene |
1238
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| Alt Symbol |
CCBP2, CCR10, CCR9, CMKBR9, D6, hD6
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| Species |
Human
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| Gene Type |
protein-coding
|
| Description |
atypical chemokine receptor 2
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| Other Description |
C-C chemokine receptor D6|CC-chemokine-binding receptor JAB61|chemokine (C-C motif) receptor 9|chemokine (C-C) receptor 9|chemokine binding protein 2|chemokine receptor CCR-10|chemokine receptor CCR-9|chemokine receptor D6|chemokine-binding protein 2|chemokine-binding protein D6
|
| Swissprots |
Q53YA1 Q96A02 Q86UN9 O00537 B2R8Y8 O00590
|
| Accessions |
AAP20651 AAP42156 CBH19238 EAW64678 EAW64679 EAW64680 EAW64681 O00590 AK313561 BAG36335 BC008816 AAH08816 BC011588 BC011631 AAH11631 BC018716 BC020558 AAH20558 BC101629 AAI01630 BC112045 AAI12046 BE901130 BT006800 AAP35446 DA853159 DQ229109 EU832737 ACE87069 U94888 AAB97728 Y12815 CAA73346 NM_001296 NP_001287
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| Function |
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein- independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1- LIMK1 signaling pathway. Activation of this pathway results in up- regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging che
|
| Subcellular Location |
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
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| Tissue Specificity |
Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. {ECO:0000269|PubMed:11238036, ECO:0000269|PubMed:22651933, ECO:0000269|PubMed:23479571}.
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