| Gene Symbol |
UGT1A9
|
| Entrez Gene |
54600
|
| Alt Symbol |
HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A9
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A9|UDP-glucuronosyltransferase 1-9|UDP-glucuronosyltransferase 1-I|UDP-glucuronosyltransferase 1A9
|
| Swissprots |
P36509 Q9HAX0 B8K285 O60656
|
| Accessions |
AAG29816 AAG30418 AAQ05894 AAQ05895 AAQ84220 AAQ84221 AAQ84222 AAQ84223 AAQ84224 AAQ84225 AAQ84226 AAQ84227 AAQ84228 AAQ84229 AAQ92914 AAQ92915 AAQ92916 AAR10772 AAR86933 AAR86934 AAT77229 AAT77230 AAT77231 AAT77232 AAY32605 AAY32606 AAY32607 AAY32608 AAY32609 AAY32610 AAY32611 AAY56382 AAY56383 EAW71054 O60656 AF056188 AAC31425 AK313510 BAG36290 AY435144 AAR95645 BC043491 BC058844 AAH58844 DQ364246 ABC96770 S55985 AAB19791 NM_021027 NP_066307
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:19545173}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine. {ECO:0000269|PubMed:18004212}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|