| Gene Symbol | Taok1 |
|---|---|
| Entrez Gene | 286993 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | TAO kinase 1 |
| Other Description | serine/threonine protein kinase TAO1|serine/threonine-protein kinase TAO1|thousand and one amino acid protein 1 |
| Swissprots | O88664 |
| Accessions | EDM05292 EDM05293 O88664 AF084205 AAC71014 NM_173327 NP_775449 |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Top Pathways | MAPK signaling pathway |
CompoZr® Knockout ZFN Kit - CKOZFN63839 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND63839 from Sigma-Aldrich
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TAOK1 siRNA (Rat) - CRR3849 from Cohesion Biosciences
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TAOK1 - MBS8222391 from MyBioSource
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shRNA set against Rat Taok1 (NM_173327.1) - SHH422984 from Creative biogene
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shRNA set against Rat Taok1(NM_173327.1) - SHL055743 from Creative biogene
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shRNA set against Mouse Taok1(NM_144825.2) - SHL055754 from Creative biogene
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shRNA set against Rat Taok1(NM_173327.1) - SHL055873 from Creative biogene
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shRNA set against Mouse Taok1(NM_144825.2) - SHL055878 from Creative biogene
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Rat TAOK1 siRNA - orb298698 from Biorbyt
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TAOK1 shRNA Plasmid (Rat) - CHR3849 from Cohesion Biosciences
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TAOK1 miRNA 3'UTR clone - MiUTR1R-07893 from Creative biogene
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