ULK2
| Gene Symbol | ULK2 |
|---|---|
| Entrez Gene | 9706 |
| Alt Symbol | ATG1B, Unc51.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | unc-51 like autophagy activating kinase 2 |
| Other Description | serine/threonine-protein kinase ULK2 |
| Swissprots | O75119 A8MY69 Q8IYT8 |
| Accessions | EAW50910 EAW50911 EAW50912 Q8IYT8 AB014523 BAA31598 AK098316 BAG53611 AK314345 AL080134 BC034988 AAH34988 BC039310 DA105030 XM_011524087 XP_011522389 XR_934124 XR_934125 NM_001142610 NP_001136082 NM_014683 NP_055498 |
| Function | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic |
| Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18936157}; Peripheral membrane protein {ECO:0000269|PubMed:18936157}. Note=Localizes to pre- autophagosomal membrane. |
| Top Pathways | Regulation of autophagy, mTOR signaling pathway |
ULK2 CRISPR/Cas9 KO Plasmid (h) - sc-402558 from Santa Cruz Biotechnology
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ULK2 HDR Plasmid (h) - sc-402558-HDR from Santa Cruz Biotechnology
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ULK2 Double Nickase Plasmid (h) - sc-402558-NIC from Santa Cruz Biotechnology
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ULK2 Double Nickase Plasmid (h2) - sc-402558-NIC-2 from Santa Cruz Biotechnology
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ULK2 CRISPR Activation Plasmid (h) - sc-402558-ACT from Santa Cruz Biotechnology
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ULK2 CRISPR Activation Plasmid (h2) - sc-402558-ACT-2 from Santa Cruz Biotechnology
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ULK2 Lentiviral Activation Particles (h) - sc-402558-LAC from Santa Cruz Biotechnology
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ULK2 Lentiviral Activation Particles (h2) - sc-402558-LAC-2 from Santa Cruz Biotechnology
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ULK2 siRNA (h) - sc-44183 from Santa Cruz Biotechnology
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ULK2 shRNA Plasmid (h) - sc-44183-SH from Santa Cruz Biotechnology
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ULK2 shRNA (h) Lentiviral Particles - sc-44183-V from Santa Cruz Biotechnology
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ULK2 RNAi - H00009706-R02 from Novus Biologicals
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MISSION® esiRNA - EHU074101 from Sigma-Aldrich
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MISSION® siRNA - SIHK2423 from Sigma-Aldrich
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MISSION® siRNA - SIHK2421 from Sigma-Aldrich
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MISSION® siRNA - SIHK2422 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22486 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22486 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11133 from Sigma-Aldrich
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ULK2 siRNA (Human) - CRH6477 from Cohesion Biosciences
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ULK2 - MBS8228006 from MyBioSource
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ULK2 shRNA Plasmid (Human) - CHH6477 from Cohesion Biosciences
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ULK2 miRNA 3'UTR clone - MiUTR3H-10131 from Creative biogene
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ULK2 miRNA 3'UTR clone - MiUTR4H-TG09663 from Creative biogene
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