| Gene Symbol | Rpe65 |
|---|---|
| Entrez Gene | 89826 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | retinal pigment epithelium-specific protein 65 |
| Other Description | all-trans-retinyl-palmitate hydrolase|retinal pigment epithelium 65|retinal pigment epithelium 65-like|retinal pigment epithelium-specific 65 kDa protein|retinoid isomerohydrolase|retinol isomerase |
| Swissprots | F1M8Q2 O70276 |
| Accessions | EDL82582 O70276 AF035673 AAC40059 NM_053562 NP_446014 |
| Function | Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Microsome membrane {ECO:0000250}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Retinal pigment epithelium specific. |
| Top Pathways | Retinol metabolism |
Recombinant Rat Retinoid isomerohydrolase(Rpe65) - CSB-YP020098RA CSB-EP020098RA CSB-BP020098RA CSB-MP020098RA from Cusabio
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Recombinant Rat RPE65 Protein - RPE65-5104R from Creative Biomart
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Retinoid isomerohydrolase (Rpe65), Recombinant Protein - MBS1239993 from MyBioSource
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