| Gene Symbol | MYO9B |
|---|---|
| Entrez Gene | 4650 |
| Alt Symbol | CELIAC4, MYR5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin IXB |
| Other Description | myosin-IXb|unconventional myosin IXb|unconventional myosin-9b|unconventional myosin-IXb |
| Swissprots | O75314 Q9UHN0 Q9NUJ2 Q13459 |
| Accessions | EAW84572 EAW84573 Q13459 AB209997 BAE06079 AB290184 BAG06734 AF020267 AAC26597 AF143684 AAF00119 AK002201 BAA92132 AY927576 BC018108 AAH18108 BC061639 BC094864 BF905466 BI001923 BI827217 CN284963 DR006748 L29149 AAA20912 XM_011528029 XP_011526331 XM_011528030 XP_011526332 XM_011528031 XP_011526333 XM_011528032 XP_011526334 XM_011528033 XP_011526335 XM_011528034 XP_011526336 XM_011528035 XP_011526337 XM_011528036 XP_011526338 XM_011528037 XP_011526339 XM_011528038 XP_011526340 XR_936183 XR_936184 XR_936185 NM_001130065 NP_001123537 NM_004145 NP_004136 |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. |
| Subcellular Location | Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. |
| Tissue Specificity | Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung. |
Myosin IXb CRISPR/Cas9 KO Plasmid (h) - sc-405395 from Santa Cruz Biotechnology
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Myosin IXb HDR Plasmid (h) - sc-405395-HDR from Santa Cruz Biotechnology
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Myosin IXb Double Nickase Plasmid (h) - sc-405395-NIC from Santa Cruz Biotechnology
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Myosin IXb Double Nickase Plasmid (h2) - sc-405395-NIC-2 from Santa Cruz Biotechnology
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Myosin IXb CRISPR Activation Plasmid (h) - sc-405395-ACT from Santa Cruz Biotechnology
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Myosin IXb CRISPR Activation Plasmid (h2) - sc-405395-ACT-2 from Santa Cruz Biotechnology
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Myosin IXb Lentiviral Activation Particles (h) - sc-405395-LAC from Santa Cruz Biotechnology
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Myosin IXb Lentiviral Activation Particles (h2) - sc-405395-LAC-2 from Santa Cruz Biotechnology
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Myosin IXb siRNA (h) - sc-61124 from Santa Cruz Biotechnology
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Myosin IXb shRNA Plasmid (h) - sc-61124-SH from Santa Cruz Biotechnology
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Myosin IXb shRNA (h) Lentiviral Particles - sc-61124-V from Santa Cruz Biotechnology
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MYO9B RNAi - H00004650-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN14868 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14868 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07782 from Sigma-Aldrich
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MYO9B siRNA (Human) - CRH3074 from Cohesion Biosciences
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shRNA set against Human MYO9B (NM_004145.3) - SHH348344 from Creative biogene
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Human MYO9B siRNA - orb263576 from Biorbyt
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MYO9B shRNA Plasmid (Human) - CHH3074 from Cohesion Biosciences
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MYO9B miRNA 3'UTR clone - MiUTR3H-04689 from Creative biogene
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MYO9B miRNA 3'UTR clone - MiUTR3H-04690 from Creative biogene
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