| Gene Symbol |
STAU2
|
| Entrez Gene |
27067
|
| Alt Symbol |
39K2, 39K3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
staufen double-stranded RNA binding protein 2
|
| Other Description |
double-stranded RNA-binding protein Staufen homolog 2|staufen homolog 2|staufen, RNA binding protein, homolog 2
|
| Swissprots |
Q9UGG6 Q6AHY7 Q9NVI5 Q96HM0 E7ER74 B7Z292 Q9NUL3 Q96HM1 B7Z1I6 B7Z8B4 E9PEI3 E9PF26 E9PF50
|
| Accessions |
EAW87003 EAW87004 EAW87005 EAW87006 EAW87007 Q9NUL3 AB210014 BAE06096 AF459097 AAN37926 AF459098 AAN37927 AK001576 BAA91766 AK002152 BAA92111 AK023314 BAB14522 AK290141 BAF82830 AK293496 BAH11522 AK293729 BAH11582 AK294466 BAH11778 AK303104 BAH13900 AK307841 AK314617 BAG37183 AL079285 AL079286 AL079288 BC008369 AAH08369 BC008370 AAH08370 BC071766 BC110447 AAI10448 BC110448 CA311807 CR627442 CAH10527 DB501161 DQ896332 ABM87331 EU176423 ABW03874 Y19062 CAB64341 NM_001164380 NP_001157852 NM_001164381 NP_001157853 NM_001164382 NP_001157854 NM_001164383 NP_001157855 NM_001164384 NP_001157856 NM_001164385 NP_001157857 NM_014393 NP_055208
|
| Function |
RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1- dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.
|